The 2016 revision of the World Health Organization classification of tumors of hematopoietic
and lymphoid tissues is characterized by a closer integration of morphology and molecular …

An international expert panel, active within the European Society for Blood and Marrow
Transplantation, European LeukemiaNet, Blood and Marrow Transplant Clinical Trial Group …

Myeloid neoplasms and acute leukemias derive from the clonal expansion of hematopoietic
cells driven by somatic gene mutations. Although assessment of morphology plays a crucial …

Background Myeloproliferative neoplasms, such as polycythemia vera, essential
thrombocythemia, and myelofibrosis, are chronic hematologic cancers with varied …

Unexplained blood cytopenias, in particular anemia, are often found in older persons. The
relationship between these cytopenias and myeloid neoplasms like myelodysplastic …

Risk stratification is critical in the care of patients with myelodysplastic syndromes (MDS).
Approximately 10% have a complex karyotype (CK), defined as more than two cytogenetic …

Germline GATA2 mutations cause cellular deficiencies with high propensity for myeloid
disease. We investigated 426 children and adolescents with primary myelodysplastic …

Refractory anemia with ring sideroblasts (RARS) is a myelodysplastic syndrome (MDS)
characterized by isolated erythroid dysplasia and 15% or more bone marrow ring …

Chronic myelomonocytic leukemia (CMML) is a myelodysplastic/myeloproliferative
neoplasm with variable clinical course. To predict the clinical outcome, we previously …

Disease overview The myelodysplastic syndromes (MDS) are a very heterogeneous group
of myeloid disorders characterized by peripheral blood cytopenias and increased risk of …