Alveolar macrophages (AMs) are the sentinel cells of the alveolar space, maintaining
homeostasis, fending off pathogens, and controlling lung inflammation. During acute lung …

The lack of effective treatments for pulmonary diseases presents a significant global health
burden, primarily due to the challenges posed by the pulmonary barrier that hinders drug …

Ex vivo-loaded white blood cells (WBC) can transfer cargo to pathological foci in the central
nervous system (CNS). Here we tested affinity ligand driven in vivo loading of WBC in order …

Long-acting formulations are designed to reduce dosing frequency and simplify dosing
schedules by providing an extended duration of action. One approach to obtain long-acting …

Biomaterials continue to evolve as complex engineered tools for interactively instructing
biological systems, aiding in the understanding and treatment of various disease states …

Macrophages act as immune scavengers and are important cell types in the homeostasis of
various tissues. Given the multiple roles of macrophages, these cells can also be found as …

Intracellular bacterial infections pose enormous challenges to food safety and public health.
Antibiotic-based polymer prodrugs have been used to treat intracellular bacterial infection …

In the last decades, nanoscale drug delivery systems have gained great attention partly due
to their ability to improve the bioavailability of water insoluble drugs. To this end, the general …

Alveolar macrophages (AMs) are lung-resident myeloid cells that sit at the interface of the
airway and lung tissue. Under homeostatic conditions, their primary function is to clear …

Intratumoral immunotherapy holds promise for improving cancer treatment efficacy.
However, rapid clearance from the tumor upon bolus volume injections limits efficacy and …