May phytophenolics alleviate aflatoxins-induced health challenges? A holistic insight on current landscape and future prospects

H Rasouli, FD Nayeri, R Khodarahmi - Frontiers in nutrition, 2022 - frontiersin.org
The future GCC-connected environmental risk factors expedited the progression of nCDs.
Indeed, the emergence of AFs is becoming a global food security concern. AFs are lethal …

Carvacrol promotes cell cycle arrest and apoptosis through PI3K/AKT signaling pathway in MCF-7 breast cancer cells

A Mari, G Mani, SN Nagabhishek, G Balaraman… - Chinese journal of …, 2021 - Springer
Objective To examine the role of carvacrol in modulating PI3K/AKT signaling involved in
human breast cancer pathogenesis using in vitro experimental model MCF-7 cells. Methods …

LDH, proliferation curves and cell cycle analysis are the most suitable assays to identify and characterize new phytotherapeutic compounds

AFL Specian, JM Serpeloni, K Tuttis, DL Ribeiro… - Cytotechnology, 2016 - Springer
Brazilian flora biodiversity has been widely investigated to identify effective and safe
phytotherapeutic compounds. Among the investigated plant species, the Byrsonima genus …

Fridericia platyphylla (Cham.) LG Lohmann root extract exerts cytotoxic and antiproliferative effects on gastric tumor cells and downregulates BCL-XL, BIRC5, and …

JM Serpeloni, AFL Specian… - Human & …, 2020 - journals.sagepub.com
Fridericia platyphylla (Cham.) LG Lohmann (FP) has cytotoxic, anti-inflammatory, and
analgesic properties. We aimed to characterize the cytotoxic and antiproliferative effects of …

Pouteria ramiflora (Mart.) Radlk. extract: Flavonoids quantification and chemopreventive effect on HepG2 cells

K Tuttis, DLMG da Costa, HL Nunes… - Journal of Toxicology …, 2018 - Taylor & Francis
ABSTRACT Pouteria ramiflora (Mart.) Radlk., popularly known as curriola, is commonly used
in Brazil as medicinal plant to treat worm infections, dysentery, pain, inflammation …

Chemical characterization of Brazilian savannah Byrsonima species (muricis) and their impact on genomic instability and chemopreventive effects

AFL Specian, K Tuttis, JM Serpeloni, DL Ribeiro… - … /Genetic Toxicology and …, 2023 - Elsevier
The identification of new drugs with few or no adverse effects is of great interest worldwide.
In cancer therapy, natural products have been used as chemopreventive and …

Machaerium hirtum (Vell.) Stellfeld Alleviates Acute Pain and Inflammation: Potential Mechanisms of Action

JA Lopes, VP Rodrigues, MMP Tangerina, LRM Rocha… - Biomolecules, 2020 - mdpi.com
Machaerium hirtum (Vell.) Stellfeld (Fabaceae) known in Brazil as “jacaranda de espinho” or
“espinheira santa nativa” is a medicinal plant commonly used in folk medicine to treat ulcers …

Phytotoxic Potential of the Crude Extract and Leaf Fractions of Machaerium hirtum on the Initial Growth of Euphorbia heterophylla And Ipomoea grandifolia

GR Ximenez, SMO Santin, MC Ignoato, LA Souza… - Planta Daninha, 2019 - SciELO Brasil
Allelopathy is the term used to define any process involving secondary metabolites
produced by plants and microorganisms that influence growth and development of …

Phytochemical study and evaluation of cytotoxicity, mutagenicity, cell cycle kinetics and gene expression of Bauhinia holophylla (Bong.) Steud. in HepG2 cells in vitro

DL Ribeiro, HL Cilião, AFL Specian, JM Serpeloni… - Cytotechnology, 2018 - Springer
Abstract Bauhinia holophylla (Bong.) Steud.(Fabaceae) is a plant used in Brazilian folk
medicine to treat diabetes and inflammation. This study evaluated the phytochemical …

Metabolites of Machaerium isadelphum as chemophenetic markers of Machaerium genus

D Patrón-González, R Ríos-Gómez… - Biochemical Systematics …, 2021 - Elsevier
Species of the genus Machaerium characteristically produce aromatic compounds, being
the isoflavonoids (isoflavanes and isoflavones), flavones, neoflavonoids, stilbenes and …