Conspectus The interrogation of reaction intermediates is key for understanding chemical
reactions; however their direct observation and study remains a considerable challenge …

Highlights•Ion mobility-mass spectrometry (IM-MS) based methods can be used to elucidate
complex glycans.•IM-MS enables coarse separation of molecular classes and rapid …

Recent advances in the gas phase vibrational spectroscopy of mass-selected ions are
described, highlighting experiments on hydrogen-bonded (HBed) clusters relevant to …

Cryogenic ion trap vibrational spectroscopy paired with quantum chemistry currently
represents the most generally applicable approach for the structural investigation of …

We review the role that gas-phase, size-selected protonated water clusters, H+ (H2O) n,
have played in unraveling the microscopic mechanics responsible for the spectroscopic …

Spectroscopy is a key analytical tool that provides valuable insight into molecular structure
and is widely used to identify chemical samples. Tagging spectroscopy is a form of action …

This article presents a general computational approach for efficient simulations of
anharmonic vibrational spectra in chemical systems. An automated local-mode vibrational …

The nature of the excess proton in liquid water has remained elusive after decades of
extensive research. In view of ultrafast structural fluctuations of bulk water scrambling the …

The infrared (IR) spectra of protonated water clusters encode precise information on the
dynamics and structure of the hydrated proton. However, the strong anharmonic coupling …

Over the last decade, the spectroscopy of cryogenically cold ions isolated in the gas phase
has been developed as a new tool for structural elucidations of biological molecules …