Renal cell carcinoma (RCC) is characterized by an infrequent number of somatic mutations.
By contrast, epigenetic aberrations are commonly found in RCC, indicating that epigenetic …

Histone methylation plays a key role in the regulation of chromatin structure, and its
dynamics regulates important cellular processes. The investigation of the role of alterations …

Abstract Background Circular RNAs (circRNAs) play important roles in tumourigenesis and
tumour progression. However, the expression profiles and functions of circRNAs in …

Protein histidine methylation is a rare post-translational modification of unknown
biochemical importance. In vertebrates, only a few methylhistidine-containing proteins have …

SET (Suppressor of variegation, Enhancer of Zeste, Trithorax) and MYND (Myeloid-Nervy-
DEAF1) domain-containing protein 2 (SMYD2) is a protein methyltransferase that methylates …

SMYD2 is a histone methyltransferase that has been reported to be an important epigenetic
regulator. This study aims to investigate SMYD2 as a prognostic indicator of clear cell renal …

Emerging evidence has demonstrated that epigenetic regulation plays a vital role in gene
expression under normal and pathological conditions. Alterations in the expression and …

Simple Summary Epigenetic modifications can regulate gene expression by altering
chromatin structure. Since the beginning of comprehensive research into changes in gene …

The chromatin structure of the mammalian genome must facilitate both precisely-controlled
DNA replication together with tightly-regulated gene transcription. This necessarily involves …

SETD3 is a member of the protein lysine methyltransferase (PKMT) family, which catalyzes
the addition of methyl group to lysine residues. However, the protein network and the …