DNA replication and RNA transcription processes compete for the same DNA template and,
thus, frequently collide. These transcription–replication collisions are thought to lead to …

Accurate DNA replication and transcription elongation are crucial for preventing the
accumulation of unreplicated DNA and genomic instability. Cells have evolved multiple …

Protein carboxymethyltransferase (Pcm) is a highly evolutionarily conserved enzyme that
initiates the conversion of abnormal isoaspartate to aspartate residues. While it is commonly …

Bacterial transcription by RNA polymerase (RNAP) is spatially organized. RNAPs
transcribing highly expressed genes locate in the nucleoid periphery, and form clusters in …

Free-living bacteria have regulatory systems that can quickly reprogram gene transcription
in response to changes in the cellular environment. The RapA ATPase, a prokaryotic …

Abstract (p) ppGpp is a nucleotide alarmone that controls bacterial response to nutrient
deprivation. Since elevated (p) ppGpp levels confer mecillinam resistance and are essential …

Fidelity of DNA replication is crucial for the accurate transmission of genetic information
across generations, yet errors still occur despite multiple control mechanisms. This study …

Survival response of the human tuberculosis pathogen, Mycobacterium tuberculosis (Mtb) to
a diverse environmental cues is governed through its versatile transcription regulatory …

Eukaryotic ribosomal DNA (rDNA) comprises tandem units of highly conserved coding
genes separated by rapidly evolving spacer DNA. The spacers of all 12 species examined …

Streptomyces are prolific producers of specialized metabolites with applications in medicine
and agriculture. These bacteria possess a large linear chromosome genetically …