Ferroptosis is a non-apoptotic form of regulated cell death characterized by the lethal
accumulation of iron-dependent membrane-localized lipid peroxides. It acts as an innate …

Mitochondria must maintain adequate amounts of metabolites for protective and biosynthetic
functions. However, how mitochondria sense the abundance of metabolites and regulate …

Systemic iron deficiency (SID), even in the absence of anaemia, worsens the prognosis and
increases mortality in heart failure (HF). Recent clinical–epidemiological studies, however …

Since the discovery of an autonomous iron–sulfur cluster (Fe–S) assembly machinery in
mitochondria, significant efforts to examine the nature of this process have been made. The …

Iron–sulfur cluster (ISC) assembly occurs in both mitochondria and cytosol. Mitochondria are
thought to export a low-molecular-mass (LMM) iron and/or sulfur species which is used as a …

Human ATP-binding cassette transporter subfamily B6 (ABCB6) is a mitochondrial ATP-
driven pump that translocates porphyrins from the cytoplasm into mitochondria for heme …

The biogenesis of iron–sulfur (Fe/S) proteins entails the synthesis and trafficking of Fe/S
clusters, followed by their insertion into target apoproteins. In eukaryotes, the multiple steps …

ATP-binding cassette transporter B6 (ABCB6), a protein essential for heme biosynthesis in
mitochondria, also functions as a heavy metal efflux pump. Here, we present cryo-electron …

Glutathione (GSH) is a pivotal tripeptide antioxidant essential for maintaining cellular redox
homeostasis and regulating diverse cellular processes. Subcellular compartmentalization of …

ABSTRACT Iron-sulfur (Fe-S) clusters are ubiquitous inorganic cofactors required for
numerous essential cellular pathways. Since they cannot be scavenged from the …