Epigenetics has been defined as 'the structural adaptation of chromosomal regions so as to
register, signal or perpetuate altered activity states.'Currently, several classes of anticancer …

Lysine acetylation is a key mechanism that regulates chromatin structure; aberrant
acetylation levels have been linked to the development of several diseases. Acetyl-lysine …

Histone lysine acetylation is critical in regulating transcription. Dysregulation of this process
results in aberrant gene expression in various diseases, including cancer. The …

The Bromodomain and Extra-Terminal Domain (BET) family of proteins is characterized by
the presence of two tandem bromodomains and an extra-terminal domain. The mammalian …

Aberrations in the epigenetic landscape are a hallmark of cancer. Alterations in enzymes
that are “writers,”“erasers,” or “readers” of histone modification marks are common …

Enhanced and deregulated expression of N-MYC, a member of the MYC family of
transcription factors, drives the development of multiple tumors, including tumors of the …

Prostate cancer remains the most frequently diagnosed cancer in men in North America, and
despite recent advances in treatment patients with metastatic disease continue to have poor …

As a conserved protein interaction module that recognizes and binds to acetylated lysine,
bromodomain (BRD) contains a deep, largely hydrophobic acetyl lysine binding site …

NUT midline carcinoma (NMC), a subtype of squamous cell cancer, is one of the most
aggressive human solid malignancies known. NMC is driven by the creation of a …

Lysine acetylation is a fundamental post-translational modification that plays an important
role in the control of gene transcription in chromatin in an ordered fashion. The …