The role of GABAergic signalling in neurodevelopmental disorders
GABAergic inhibition shapes the connectivity, activity and plasticity of the brain. A series of
exciting new discoveries provides compelling evidence that disruptions in a number of key …
exciting new discoveries provides compelling evidence that disruptions in a number of key …
Behavioral neuroscience of autism
Autism spectrum disorder (ASD) is a neurodevelopmental disorder. Several genetic causes
of ASD have been identified and this has enabled researchers to construct mouse models …
of ASD have been identified and this has enabled researchers to construct mouse models …
The autism biomarkers consortium for clinical trials (ABC-CT): scientific context, study design, and progress toward biomarker qualification
Clinical research in neurodevelopmental disorders remains reliant upon clinician and
caregiver measures. Limitations of these approaches indicate a need for objective …
caregiver measures. Limitations of these approaches indicate a need for objective …
A myelin-related transcriptomic profile is shared by Pitt–Hopkins syndrome models and human autism spectrum disorder
Autism spectrum disorder (ASD) is genetically heterogeneous with convergent
symptomatology, suggesting common dysregulated pathways. In this study, we analyzed …
symptomatology, suggesting common dysregulated pathways. In this study, we analyzed …
[HTML][HTML] Drug development for autism spectrum disorder (ASD): progress, challenges, and future directions
In 2017, facing lack of progress and failures encountered in targeted drug development for
Autism Spectrum Disorder (ASD) and related neurodevelopmental disorders, the ISCTM …
Autism Spectrum Disorder (ASD) and related neurodevelopmental disorders, the ISCTM …
Re-expression of SynGAP protein in adulthood improves translatable measures of brain function and behavior
TK Creson, C Rojas, E Hwaun, T Vaissiere, M Kilinc… - Elife, 2019 - elifesciences.org
It remains unclear to what extent neurodevelopmental disorder (NDD) risk genes retain
functions into adulthood and how they may influence disease phenotypes. SYNGAP1 …
functions into adulthood and how they may influence disease phenotypes. SYNGAP1 …
Advances in nonhuman primate models of autism: Integrating neuroscience and behavior
MD Bauman, CM Schumann - Experimental neurology, 2018 - Elsevier
Given the prevalence and societal impact of autism spectrum disorders (ASD), there is an
urgent need to develop innovative preventative strategies and treatments to reduce the …
urgent need to develop innovative preventative strategies and treatments to reduce the …
Increased subcortical neural responses to repeating auditory stimulation in children with autism spectrum disorder
M Font-Alaminos, M Cornella, J Costa-Faidella… - Biological …, 2020 - Elsevier
Recent research has highlighted atypical reactivity to sensory stimulation as a core symptom
in children with autism spectrum disorder (ASD). However, little is known about the …
in children with autism spectrum disorder (ASD). However, little is known about the …
Disrupted circuits in mouse models of autism spectrum disorder and intellectual disability
Highlights•Mouse models of autism and intellectual disability display circuit-level
alterations.•These deficits link genetic disruptions to behavioral phenotypes.•Phenotypes …
alterations.•These deficits link genetic disruptions to behavioral phenotypes.•Phenotypes …
Auditory processing in rodent models of autism: a systematic review
M Wilde, L Constantin, PR Thorne… - Journal of …, 2022 - Springer
Autism is a complex condition with many traits, including differences in auditory sensitivity.
Studies in human autism are plagued by the difficulty of controlling for aetiology, whereas …
Studies in human autism are plagued by the difficulty of controlling for aetiology, whereas …