Nanoparticle radio-enhancement: principles, progress and application to cancer treatment

Z Kuncic, S Lacombe - Physics in Medicine & Biology, 2018 - iopscience.iop.org
Enhancement of radiation effects by high-atomic number nanoparticles (NPs) has been
increasingly studied for its potential to improve radiotherapeutic efficacy. The underlying …

Physical basis and biological mechanisms of gold nanoparticle radiosensitization

KT Butterworth, SJ McMahon, FJ Currell, KM Prise - Nanoscale, 2012 - pubs.rsc.org
The unique properties of nanomaterials, in particular gold nanoparticles (GNPs) have
applications for a wide range of biomedical applications. GNPs have been proposed as …

Gold nanoparticles in radiotherapy and recent progress in nanobrachytherapy

M Laprise‐Pelletier, T Simão… - Advanced healthcare …, 2018 - Wiley Online Library
Over the last few decades, gold nanoparticles (GNPs) have emerged as “radiosensitizers” in
oncology. Radiosensitizers are additives that can enhance the effects of radiation on …

Chemical enhancement by nanomaterials under X-ray irradiation

NN Cheng, Z Starkewolf, RA Davidson… - Journal of the …, 2012 - ACS Publications
We report here a new phenomenon of dynamic enhancement of chemical reactions by
nanomaterials under hard X-ray irradiation. The nanomaterials were gold and platinum …

Optimising element choice for nanoparticle radiosensitisers

SJ McMahon, H Paganetti, KM Prise - Nanoscale, 2016 - pubs.rsc.org
There is considerable interest in the use of heavy atom nanoparticles as theranostic contrast
agents due to their high radiation cross-section compared to soft tissue. However, published …

Monte Carlo investigation of the increased radiation deposition due to gold nanoparticles using kilovoltage and megavoltage photons in a 3D randomized cell model

M Douglass, E Bezak, S Penfold - Medical physics, 2013 - Wiley Online Library
Purpose: Investigation of increased radiation dose deposition due to gold nanoparticles
(GNPs) using a 3D computational cell model during x‐ray radiotherapy. Methods: Two GNP …

LET-dependent radiosensitization effects of gold nanoparticles for proton irradiation

S Li, S Penninckx, L Karmani, AC Heuskin… - …, 2016 - iopscience.iop.org
The development of new modalities and protocols is of major interest to improve the
outcome of cancer treatment. Given the appealing physical properties of protons and the …

Cancer treatment using different shapes of gold-based nanomaterials in combination with conventional physical techniques

S Tarantino, AP Caricato, R Rinaldi, C Capomolla… - Pharmaceutics, 2023 - mdpi.com
The conventional methods of cancer treatment and diagnosis, such as radiotherapy,
chemotherapy, and computed tomography, have developed a great deal. However, the …

Optimal energy for cell radiosensitivity enhancement by gold nanoparticles using synchrotron-based monoenergetic photon beams

WN Rahman, S Corde, N Yagi… - International journal …, 2014 - Taylor & Francis
Gold nanoparticles have been shown to enhance radiation doses delivered to biological
targets due to the high absorption coefficient of gold atoms, stemming from their high atomic …

Radiosensitization by gold nanoparticles: impact of the size, dose rate, and photon energy

KV Morozov, MA Kolyvanova, ME Kartseva… - Nanomaterials, 2020 - mdpi.com
Gold nanoparticles (GNPs) emerged as promising antitumor radiosensitizers. However, the
complex dependence of GNPs radiosensitization on the irradiation conditions remains …