Gut microbiota and dysbiosis in Alzheimer's disease: implications for pathogenesis and treatment

S Liu, J Gao, M Zhu, K Liu, HL Zhang - Molecular neurobiology, 2020 - Springer
Understanding how gut flora influences gut-brain communications has been the subject of
significant research over the past decade. The broadening of the term “microbiota-gut-brain …

Colonocyte metabolism shapes the gut microbiota

Y Litvak, MX Byndloss, AJ Bäumler - Science, 2018 - science.org
BACKGROUND An imbalance in the colonic microbiota might underlie many human
diseases, but the mechanisms that balance our microbial self during homeostasis have long …

The role of the canine gut microbiome and metabolome in health and gastrointestinal disease

R Pilla, JS Suchodolski - Frontiers in veterinary science, 2020 - frontiersin.org
The gut microbiome contributes to host metabolism, protects against pathogens, educates
the immune system, and, through these basic functions, affects directly or indirectly most …

Sub-1.4 cm3 capsule for detecting labile inflammatory biomarkers in situ

ME Inda-Webb, M Jimenez, Q Liu, NV Phan, J Ahn… - Nature, 2023 - nature.com
Transient molecules in the gastrointestinal tract such as nitric oxide and hydrogen sulfide
are key signals and mediators of inflammation. Owing to their highly reactive nature and …

Fiber supplementation protects from antibiotic-induced gut microbiome dysbiosis by modulating gut redox potential

S Penumutchu, BJ Korry, K Hewlett… - Nature …, 2023 - nature.com
Antibiotic-induced gut dysbiosis (AID) is a frequent and serious side effect of antibiotic use
and mitigating this dysbiosis is a critical therapeutic target. We propose that the host diet can …

Short-chain fatty acids and lipopolysaccharide as mediators between gut dysbiosis and amyloid pathology in Alzheimer's disease

M Marizzoni, A Cattaneo, P Mirabelli… - Journal of …, 2020 - content.iospress.com
Background: Metagenomic data support an association between certain bacterial strains
and Alzheimer's disease (AD), but their functional dynamics remain elusive. Objective: To …

Microbial transmission in animal social networks and the social microbiome

A Sarkar, S Harty, KVA Johnson, AH Moeller… - Nature ecology & …, 2020 - nature.com
Host-associated microbiomes play an increasingly appreciated role in animal metabolism,
immunity and health. The microbes in turn depend on their host for resources and can be …

Linking oxidative stress and proteinopathy in Alzheimer's disease

C Sharma, SR Kim - Antioxidants, 2021 - mdpi.com
Proteinopathy and excessive production of reactive oxygen species (ROS), which are the
principal features observed in the Alzheimer's disease (AD) brain, contribute to neuronal …

Therapeutic opportunities in inflammatory bowel disease: mechanistic dissection of host-microbiome relationships

DR Plichta, DB Graham, S Subramanian, RJ Xavier - Cell, 2019 - cell.com
The current understanding of inflammatory bowel disease (IBD) pathogenesis implicates a
complex interaction between host genetics, host immunity, microbiome, and environmental …

Phytochemicals as modifiers of gut microbial communities

G Dingeo, A Brito, H Samouda, M Iddir, MR La Frano… - Food & function, 2020 - pubs.rsc.org
A healthy gut microbiota (GM) is paramount for a healthy lifestyle. Alterations of the GM have
been involved in the aetiology of several chronic diseases, including obesity and type 2 …