Background. Growth hormone (GH) and insulinlike growth factor (IGF1) are fundamental
in skeletal growth during puberty and bone health throughout life. GH increases tissue …

Osteoporosis is a metabolic bone disorder that is characterized by low bone mass and micro-
architectural deterioration of bone tissue. Fractures of the proximal femur, the vertebrae and …

Introduction The application of high-resolution peripheral quantitative computed tomography
(HR-pQCT) to assess bone microarchitecture has grown rapidly since its introduction in …

Background Osteoporosis research has focused on vertebral fractures and trabecular bone
loss. However, non-vertebral fractures at predominantly cortical sites account for 80% of all …

The primary goal of this study was to assess peripheral bone microarchitecture and strength
in postmenopausal women with type 2 diabetes with fragility fractures (DMFx) and to …

Context: Cross-sectional epidemiological studies have found that patients with type 2
diabetes mellitus (T2DM) have a higher incidence of certain fragility fractures despite normal …

Quantitative cortical microarchitectural end points are important for understanding structure–
function relations in the context of fracture risk and therapeutic efficacy. This technique study …

The structure of human cortical bone evolves over multiple length scales from its basic
constituents of collagen and hydroxyapatite at the nanoscale to osteonal structures at near …

Chronic kidney disease (CKD) patients may have high rates of bone loss and fractures, but
microarchitectural and biochemical mechanisms of bone loss in CKD patients have not been …

In this crosssectional study, we aimed to predict agerelated changes in bone
microarchitecture and strength at the distal radius (DR) and distal tibia (DT) in 644 Canadian …