The amyloid-β oligomer (AβO) hypothesis was introduced in 1998. It proposed that the brain
damage leading to Alzheimer's disease (AD) was instigated by soluble, ligand-like AβOs …

Ischemic stroke refers to the disorder of blood supply of local brain tissue caused by various
reasons. It has high morbidity and mortality worldwide. Astrocytes are the most abundant …

Importance Insulin modulates aspects of brain function relevant to Alzheimer disease and
can be delivered to the brain using intranasal devices. To date, the use of intranasal insulin …

Astrocytes play important roles in numerous central nervous system disorders including
autoimmune inflammatory, hypoxic, and degenerative diseases such as Multiple Sclerosis …

In the last decade, much attention has been devoted to the effects of nutrient-related signals
on brain development and cognitive functions. A turning point was the discovery that brain …

The blood-brain barrier (BBB) is a major functional barrier in the central nervous system
(CNS), and inhibits the extravasation of intravascular contents and transports various …

Alzheimer's disease (AD) is the main type of dementia and is a disease with a profound
socioeconomic burden due to the lack of effective treatment. In addition to genetics and …

The epidemiological connection between diabetes, obesity, and dementia represents an
important public health challenge but also an opportunity to further understand these …

Alzheimer's disease (AD) is a chronic neurodegenerative disorder associated with
dementia. To overcome the limitations of diagnosis and treatment nanotechnology research …

Neurodegenerative diseases including Alzheimer's disease, Parkinson's disease,
Huntington disease and amyotrophic lateral sclerosis throw a heavy burden on families and …