The dynamic interactions of cancer cells with their microenvironment consisting of stromal
cells (cellular part) and extracellular matrix (ECM) components (non-cellular) is essential to …

Fibroblasts are the most abundant “non-cancerous” cells in tumors. However, it remains
largely unknown how these cancer-associated fibroblasts (CAFs) promote tumor growth and …

From the dawn of civilization, humanity has dreamed of immortality. So why didn't the
discovery of the anti-aging properties of mTOR inhibitors change the world forever? I will …

Significance: In the last years, metabolic reprogramming, fluctuations in bioenergetic fuels,
and modulation of oxidative stress became new key hallmarks of tumor development. In …

Increased collagen expression in tumors is associated with increased risk of metastasis, and
triple-negative breast cancer (TNBC) has the highest propensity to develop distant …

It has been over 20 years since the discovery that caveolar lipid rafts function as signalling
organelles. Lipid rafts create plasma membrane heterogeneity, and caveolae are the most …

Metabolic synergy or metabolic coupling between glycolytic stromal cells (Warburg effect)
and oxidative cancer cells occurs in human breast cancers and promotes tumor growth. The …

Rapamycin (sirolimus) and other rapalogs (everolimus) are anti-cancer and anti-aging
drugs, which delay cancer by directly targeting pre-cancerous cells and, indirectly, by …

With a better understanding of the etiology of breast cancer, molecularly targeted drugs have
been developed and are being testing for the treatment and prevention of breast cancer …

Adipose tissue is a reservoir of Mesenchymal Stem Cells (Adipose-derived Mesenchymal
Stem Cells, ASCs), endowed with regenerative properties. Fat graft was proposed for breast …