Since their discovery in the 1980s and 1990s, the human protein lysine acetyltransferase
encoded by the paralogous p300 and CBP genes has received much interest. p300/CBP …

Protein semisynthesis—defined herein as the assembly of a protein from a combination of
synthetic and recombinant fragments—is a burgeoning field of chemical biology that has …

Significant resources in early drug discovery are spent unknowingly pursuing artifacts and
promiscuous bioactive compounds, while understanding the chemical basis for these …

CBP/p300, functioning as histone acetyltransferases and transcriptional co-factors,
represents an attractive target for various diseases, including malignant tumor. The …

Histone acetyltransferases (HATs) are implicated as both oncogene and nononcogene
dependencies in diverse human cancers. Acetyl-CoA-competitive HAT inhibitors have …

Aging is a significant risk factor for Alzheimer's disease (AD), although the precise
mechanism and molecular basis of AD are not yet fully understood. Epigenetic mechanisms …

The acetylation of histone and non-histone proteins controls a great deal of cellular
functions, thereby affecting the entire organism, including the brain. Acetylation …

Post-translational histone modifications play key roles in gene regulation, development and
differentiation, but their dynamics in living organisms remain almost completely unknown. To …

Transcription activation involves RNA polymerase II (Pol II) recruitment and release from the
promoter into productive elongation, but how specific chromatin regulators control these …

T-regulatory (Treg) cells are like other cells present throughout the body in being subject to
biochemical modifications in response to extracellular signals. An important component of …