Research involving nonhuman primates (NHPs) has played a vital role in many of the
medical and scientific advances of the past century. NHPs are used because of their …

Origin of the adrenogonadal primordium The adrenal glands develop from 2 separate
embryologic tissues: the medulla is derived from neural crest cells originating in proximity to …

Serono Symposia International convened an expert panel to review the impact of
environmental influences on the regulation of pubertal onset and progression while …

The monitoring of endocrine markers that inform about an animal's physiological state has
become an invaluable tool for studying the behavioral ecology of primates. While the …

The human adrenal produces more 19 carbon (C 19) steroids, by mass, than either
glucocorticoids or mineralocorticoids. However, the mechanisms regulating adrenal C 19 …

The hypothalamic-pituitary-adrenal axis (HPAA) is highly responsive to social challenges.
Because stress hormones can have negative developmental and health consequences, this …

Analytical advancements, especially methods using gas or liquid chromatography tandem
mass spectrometry, have allowed more specific and reliable measurement of multiple …

Adrenarche reflects the maturation of the adrenal zona reticularis resulting in increased
secretion of the adrenal androgen precursor DHEA and its sulphate ester DHEAS …

We have previously shown that hexarelin, a novel GH-releasing peptide (GHRP), is able to
elicit GH release when administered iv, sc or by mouth and that it is a more potent GH …

Adrenarche, the prepubertal onset of adrenal production of dehydroepiandrosterone sulfate
(DHEAS), is a distinctive aspect of the human life course. Yet its evolutionary origins remain …