Chronic pain is a common, complex and unpleasant sensation following nerve injury, tissue
trauma, inflammatory diseases, infection and cancer. It affects up to 25% of adults and is …

Background Paclitaxel is a taxane-based chemotherapeutic agent used as a treatment in
breast cancer. There is no effective prevention or treatment strategy for the most common …

Paclitaxel, a powerful anti-neoplastic drug, often causes pathological pain, which
significantly reduces the quality of life in patients. Paclitaxel-induced pain includes pain that …

Background: Nefopam is a centrally acting non-opioid analgesic agent. Its analgesic
properties may be related to the inhibitions of monoamine reuptake and the N-methyl-D …

Chemotherapy utilizing cytotoxic drugs, such as paclitaxel (PTX), is still a commonly used
therapeutic approach to treat both localized and metastasized cancers. Unlike traditional …

Short-lived reactive nitrogen species and reactive oxygen species have acquired significant
attention in the field of biomedical science. Nitric oxide (NO), which was thought to be an …

Background Diabetic peripheral neuropathy (DPN) involves a very complex pathogenesis,
and there is no neuro-specific marker for risk prediction. Neuron-specific enolase (NSE), a …

Xylopic acid, a diterpenoid isolated from the fruits of Xylopia aethiopica has demonstrated
analge-sic properties in acute pain models. It was therefore evaluated for its analgesic …

The present study investigated the hypothesis that urinary levels of N telopeptide (NTx) can
be used to predict the anti‑nociceptive responses of zoledronic acid and paclitaxel on bone …

Background: Leaf extracts of Ficus exasperata has been used traditionally in Ghana for the
management of sprains, sore eyes, rheumatism and arthritis. Objective: This study evaluates …