In Silico design of a multi-epitope vaccine for Human Parechovirus: Integrating immunoinformatics and computational techniques

A Sarker, MM Rahman, C Khatun, C Barai, N Roy… - PloS one, 2024 - journals.plos.org
Human parechovirus (HPeV) is widely recognized as a severe viral infection affecting infants
and neonates. Belonging to the Picornaviridae family, HPeV is categorized into 19 distinct …

Global characterization of GH11 family xylanases genes in Neostagonosporella sichuanensis and functional analysis of Nsxyn1 and Nsxyn2

L Liu, C Li, F Liang, S Han, S Li, C Yang… - Frontiers in …, 2024 - frontiersin.org
Rhombic-spot disease, caused mainly by Neostagonosporella sichuanensis, significantly
impacts the yield and quality of fishscale bamboo (Phyllostachys heteroclada). Xylanases …

Vaccination with OprB porin, and its epitopes offers protection against A. baumannii infections in mice

Z Raoufi, S Abdollahi - International Immunopharmacology, 2024 - Elsevier
A. baumannii is a deadly antimicrobial resistance pathogen that acquires drug resistance
through different mechanisms. Therefore, it is necessary to investigate all its virulence …

In Silico Analysis of the ROP29 Protein as a Vaccine Candidate Against Toxoplasma gondii

A Karimipour-Saryazdi, F Ghaffarifar… - Journal of …, 2024 - Wiley Online Library
The progression of Toxoplasma gondii (T. gondii) invasion is aided by rhoptry proteins
(ROPs), which are also crucial for the parasite's survival in host cells. In this study, in silico …

Protein structure classification based on X-ray laser induced Coulomb explosion

T André, I Dawod, S Cardoch, E De Santis… - arXiv preprint arXiv …, 2024 - arxiv.org
We simulated the Coulomb explosion dynamics due to the fast ionization induced by high-
intensity X-rays in six proteins that share similar atomic content and shape. We followed and …

Implications of trinodal inhibitions and drug repurposing in MAPK pathway: A putative remedy for breast cancer

S Majumder, E Lodh, T Chowdhury - Computational Biology and Chemistry, 2024 - Elsevier
Breast cancer has been one of the supreme causes of cancer-related deaths among women
worldwide. To make the case even more compounded, due to innate or acquired causes …

In silico–guided synthesis of a new, highly soluble, and anti‐melanoma flavone glucoside: Skullcapflavone II‐6′‐Oβ‐glucoside

TS Chang, HY Ding, TY Wang, JY Wu… - Biotechnology and …, 2024 - Wiley Online Library
Guided by in silico analysis tools and biotransformation technology, new derivatives of
natural compounds with heightened bioactivities can be explored and synthesized …

[HTML][HTML] Completing the pieces of a puzzle: in-depth probing of Toxoplasma gondii rhoptry protein 4 as a promising target for vaccination using an in-silico approach

M Foroutan, MM Shadravan - Clinical and Experimental …, 2024 - pmc.ncbi.nlm.nih.gov
The present study aimed to evaluate the key characteristics of Toxoplasma gondii rhoptry
protein 4 (TgROP4), including physicochemical parameters, structural features …

Development of new drug candidate for the inhibition of Nipah virus phosphoprotein by Quercetin Derivatives through in silico drug design approaches

A Berkane, N Kundu, AA Munia, B Chakrabarty… - Journal of the Indian …, 2024 - Elsevier
Abstract The Nipah virus (NiV) is a pathogenic infection that can cause a pandemic, hence
presenting a substantial risk to both human and animal communities. Despite its virulence …

Untangling the Mitochondrial Web: An In-Silico Analysis of Genetic Mutations, Protein Interactions, and tRNA Dynamics in Oxidative Phosphorylation and Disc …

M Collins, B Pearce - 2024 - researchsquare.com
Mitochondrial dysfunction and impaired oxidative phosphorylation play a crucial role in the
pathogenesis of various non-communicable and degenerative diseases. Research indicates …