Biological function of long non-coding RNA (LncRNA) Xist
W Wang, L Min, X Qiu, X Wu, C Liu, J Ma… - Frontiers in cell and …, 2021 - frontiersin.org
Long non-coding RNAs (lncRNAs) regulate gene expression in a variety of ways at
epigenetic, chromatin remodeling, transcriptional, and translational levels. Accumulating …
epigenetic, chromatin remodeling, transcriptional, and translational levels. Accumulating …
The two sides of YY1 in cancer: a friend and a foe
Yin Yang 1 (YY1), a dual function transcription factor, is known to regulate transcriptional
activation and repression of many genes associated with multiple cellular processes …
activation and repression of many genes associated with multiple cellular processes …
Unusual maintenance of X chromosome inactivation predisposes female lymphocytes for increased expression from the inactive X
J Wang, CM Syrett, MC Kramer… - Proceedings of the …, 2016 - National Acad Sciences
Females have a greater immunological advantage than men, yet they are more prone to
autoimmune disorders. The basis for this sex bias lies in the X chromosome, which contains …
autoimmune disorders. The basis for this sex bias lies in the X chromosome, which contains …
Identification of Spen as a crucial factor for Xist function through forward genetic screening in haploid embryonic stem cells
A Monfort, G Di Minin, A Postlmayr, R Freimann, F Arieti… - Cell reports, 2015 - cell.com
In mammals, the noncoding Xist RNA triggers transcriptional silencing of one of the two X
chromosomes in female cells. Here, we report a genetic screen for silencing factors in X …
chromosomes in female cells. Here, we report a genetic screen for silencing factors in X …
Xist deletional analysis reveals an interdependency between Xist RNA and polycomb complexes for spreading along the inactive X
Summary During X-inactivation, Xist RNA spreads along an entire chromosome to establish
silencing. However, the mechanism and functional RNA elements involved in spreading …
silencing. However, the mechanism and functional RNA elements involved in spreading …
GATA transcription factors drive initial Xist upregulation after fertilization through direct activation of long-range enhancers
L Ravid Lustig, A Sampath Kumar, T Schwämmle… - Nature Cell …, 2023 - nature.com
X-chromosome inactivation (XCI) balances gene expression between the sexes in female
mammals. Shortly after fertilization, upregulation of Xist RNA from one X chromosome …
mammals. Shortly after fertilization, upregulation of Xist RNA from one X chromosome …
Xist localization and function: new insights from multiple levels
A Cerase, G Pintacuda, A Tattermusch, P Avner - Genome biology, 2015 - Springer
In female mammals, one of the two X chromosomes in each cell is transcriptionally silenced
in order to achieve dosage compensation between the genders in a process called X …
in order to achieve dosage compensation between the genders in a process called X …
X-chromosome inactivation: new insights into cis and trans regulation
X-chromosome inactivation (XCI) is a developmentally associated process that evolved in
mammals to enable gene dosage compensation between XX and XY individuals. In …
mammals to enable gene dosage compensation between XX and XY individuals. In …
The X chromosome in space
T Jégu, E Aeby, JT Lee - Nature Reviews Genetics, 2017 - nature.com
Extensive 3D folding is required to package a genome into the tiny nuclear space, and this
packaging must be compatible with proper gene expression. Thus, in the well-hierarchized …
packaging must be compatible with proper gene expression. Thus, in the well-hierarchized …
The molecular and nuclear dynamics of X-chromosome inactivation
In female eutherian mammals, dosage compensation of X-linked gene expression is
achieved during development through transcriptional silencing of one of the two X …
achieved during development through transcriptional silencing of one of the two X …