Melioidosis: evolving concepts in epidemiology, pathogenesis, and treatment

BJ Currie - Seminars in respiratory and critical care medicine, 2015 - thieme-connect.com
Infection with Burkholderia pseudomallei can result in asymptomatic seroconversion, a
single skin lesion that may or may not heal spontaneously, a pneumonia which can be …

Molecular Insights into Burkholderia pseudomallei and Burkholderia mallei Pathogenesis

EE Galyov, PJ Brett, D DeShazer - Annual review of …, 2010 - annualreviews.org
Burkholderia pseudomallei and Burkholderia mallei are closely related gram-negative
bacteria that can cause serious diseases in humans and animals. This review summarizes …

Activities of daily living associated with acquisition of melioidosis in northeast Thailand: a matched case-control study

D Limmathurotsakul, M Kanoksil… - PLoS neglected …, 2013 - journals.plos.org
Background Melioidosis is a serious infectious disease caused by the Category B select
agent and environmental saprophyte, Burkholderia pseudomallei. Most cases of naturally …

Melioidosis: clinical impact and public health threat in the tropics

R Perumal Samy, BG Stiles, G Sethi… - PLoS neglected tropical …, 2017 - journals.plos.org
This review briefly summarizes the geographical distribution and clinical impact of
melioidosis, especially in the tropics. Burkholderia pseudomallei (a gram-negative …

Burkholderia pseudomallei and Burkholderia mallei vaccines: Are we close to clinical trials?

RW Titball, MN Burtnick, GJ Bancroft, P Brett - Vaccine, 2017 - Elsevier
B. pseudomallei is the cause of melioidosis, a serious an often fatal disease of humans and
animals. The closely related bacterium B. mallei, which cases glanders, is considered to be …

Present and future therapeutic strategies for melioidosis and glanders

DM Estes, SW Dow, HP Schweizer… - Expert review of anti …, 2010 - Taylor & Francis
Burkholderia pseudomallei and Burkholderia mallei are the causative agents of melioidosis
and glanders, respectively. Both Gram-negative pathogens are endemic in many parts of the …

Macrophage and Galleria mellonella infection models reflect the virulence of naturally occurring isolates of B. pseudomallei, B. thailandensis and B. oklahomensis

ME Wand, CM Müller, RW Titball, SL Michell - BMC microbiology, 2011 - Springer
Background Burkholderia pseudomallei is the causative agent of melioidosis, a tropical
disease of humans with a variable and often fatal outcome. In murine models of infection …

Layered and integrated medical countermeasures against Burkholderia pseudomallei infections in C57BL/6 mice

CP Klimko, JL Shoe, NO Rill, M Hunter… - Frontiers in …, 2022 - frontiersin.org
Burkholderia pseudomallei, the gram-negative bacterium that causes melioidosis, is
notoriously difficult to treat with antibiotics. A significant effort has focused on identifying …

Development of Vaccines Against Burkholderia Pseudomallei

N Patel, L Conejero, M De Reynal, A Easton… - Frontiers in …, 2011 - frontiersin.org
Burkholderia pseudomallei is a Gram-negative bacterium which is the causative agent of
melioidosis, a disease which carries a high mortality and morbidity rate in endemic areas of …

Novel multi-component vaccine approaches for Burkholderia pseudomallei

L Morici, AG Torres, RW Titball - Clinical & Experimental …, 2019 - academic.oup.com
Burkholderia pseudomallei is the causative agent of melioidosis. Historically believed to be
a relatively rare human disease in tropical countries, a recent study estimated that …