Despite their small size and anucleate status, platelets have diverse roles in vascular
biology. Not only are platelets the cellular mediator of thrombosis, but platelets are also …

Cerebral malaria is among the major causes of malaria-associated mortality and effective
adjunctive therapeutic strategies are currently lacking. Central pathophysiological processes …

Malaria, a mosquito‐borne infectious disease caused by parasites of the genus Plasmodium
continues to be a major health problem worldwide. The unicellular Plasmodium‐parasites …

Beyond platelets function in hemostasis, there is emerging evidence to suggest that platelets
contribute crucially to inflammation and immune responses. Therefore, considering the …

More than a century after the discovery of Plasmodium spp. parasites, the pathogenesis of
severe malaria is still not well understood. The majority of malaria cases are caused by …

Central nervous system (CNS) infections continue to be an important cause of morbidity and
mortality. Microbial invasion and traversal of the blood–brain barrier is a prerequisite for …

Platelets are anucleate cell fragments known for their central role in coagulation and
vascular integrity. However, it is becoming increasingly clear that platelets contribute to …

Severe malaria has a high mortality rate (15–20%) despite treatment with effective
antimalarial drugs. Adjunctive therapies for severe malaria that target the underlying disease …

Piezo proteins (Piezo1 and Piezo2) are recently identified mechanically activated cation
channels in eukaryotic cells and associated with physiological responses to touch, pressure …

In the century since the discovery of the ABO blood groups, numerous associations between
ABO groups and disease have been noted. However, the selection pressures defining the …