Investigating the molecular mechanisms of learning and memory using Caenorhabditis elegans

A Rahmani, YL Chew - Journal of Neurochemistry, 2021 - Wiley Online Library
Learning is an essential biological process for survival since it facilitates behavioural
plasticity in response to environmental changes. This process is mediated by a wide variety …

The logic of transgenerational inheritance: timescales of adaptation

T Sengupta, R Kaletsky… - Annual review of cell and …, 2023 - annualreviews.org
Myriad mechanisms have evolved to adapt to changing environments. Environmental stimuli
alter organisms' physiology to create memories of previous environments. Whether these …

Bacterial diet affects the age-dependent decline of associative learning in Caenorhabditis elegans

S Higurashi, S Tsukada, BM Aleogho, JH Park… - Elife, 2023 - elifesciences.org
The causality and mechanism of dietary effects on brain aging are still unclear due to the
long time scales of aging. The nematode Caenorhabditis elegans has contributed to aging …

GNAQ mutations drive port wine birthmark-associated Sturge-Weber syndrome: a review of pathobiology, therapies, and current models

WK Van Trigt, KM Kelly, CCW Hughes - Frontiers in Human …, 2022 - frontiersin.org
Port-wine birthmarks (PWBs) are caused by somatic, mosaic mutations in the G protein
guanine nucleotide binding protein alpha subunit q (GNAQ) and are characterized by the …

[HTML][HTML] Neuronal activation of Gαq EGL-30/GNAQ late in life rejuvenates cognition across species

ME Stevenson, G Bieri, R Kaletsky, JS Ange… - Cell reports, 2023 - cell.com
Loss of cognitive function with age is devastating. EGL-30/GNAQ and G αq signaling
pathways are highly conserved between C. elegans and mammals, and murine Gnaq is …

Atmospheric particulate matter impairs cognition by modulating synaptic function via the nose-to-brain route

C Liang, Y Jiang, T Zhang, Y Ji, Y Zhang, Y Sun… - Science of The Total …, 2023 - Elsevier
Atmospheric particulate matter (PM), a ubiquitous air pollutant, is the leading environmental
risk factor for mortality worldwide. Experimental and epidemiological studies consistently …

The redundancy and diversity between two novel PKC isotypes that regulate learning in Caenorhabditis elegans

S Hiroki, Y Iino - Proceedings of the National Academy of …, 2022 - National Acad Sciences
The nematode Caenorhabditis elegans learns the concentration of NaCl and moves toward
the previously experienced concentration. In this behavior, the history of NaCl concentration …

[HTML][HTML] Insulin/IGF signaling regulates presynaptic glutamate release in aversive olfactory learning

D Cheng, JS Lee, M Brown, MS Ebert, PT McGrath… - Cell Reports, 2022 - cell.com
Insulin/insulin-like growth factor (IGF) receptor signaling (IIS) supports context-dependent
learning in vertebrates and invertebrates. Here, we identify cell-specific mechanisms of IIS …

Behavioral plasticity

Y Zhang, Y Iino, WR Schafer - Genetics, 2024 - academic.oup.com
Behavioral plasticity allows animals to modulate their behavior based on experience and
environmental conditions. Caenorhabditis elegans exhibits experience-dependent changes …

Caenorhabditis elegans learning in a structured maze is a multisensory behavior

E Gourgou, K Adiga, A Goettemoeller, C Chen, AL Hsu - Iscience, 2021 - cell.com
We show that C. elegans nematodes learn to associate food with a combination of
proprioceptive cues and information on the structure of their surroundings (maze), perceived …