In the past decade, single-cell technologies have proliferated and improved from their
technically challenging beginnings to become common laboratory methods capable of …

Microglia were first recognized as a distinct cell population in the CNS one century ago. For
a long time, they were primarily considered to be phagocytes responsible for removing …

Major depressive disorder (MDD) has an enormous impact on global disease burden,
affecting millions of people worldwide and ranking as a leading cause of disability for almost …

Single-cell sequencing technologies, including transcriptomic and epigenomic assays, are
transforming our understanding of the cellular building blocks of neural circuits. By directly …

Alzheimer's disease (AD) is the most common form of dementia but has no effective
treatment. A comprehensive investigation of cell type-specific responses and cellular …

Primary somatosensory neurons are specialized to transmit specific types of sensory
information through differences in cell size, myelination, and the expression of distinct …

Diverse cell types in tissues have distinct gene expression programs, chromatin states, and
nuclear architectures. To correlate such multimodal information across thousands of single …

Highlights•Technologies such as single-cell RNA sequencing have rapidly progressed in
recent years.•Various methods exist for preparing libraries for sequencing, each with its own …

The X-linked gene encoding MECP2 is involved in two severe and complex
neurodevelopmental disorders. Loss of function of the MeCP2 protein underlies Rett …

Rett syndrome (RTT) is an X-linked neurodevelopmental disorder caused by loss-of-function
heterozygous mutations of methyl CpG-binding protein 2 (MECP2) on the X chromosome in …