Assembly-line polyketide synthases (PKSs) are among the most complex protein
machineries known in nature, responsible for the biosynthesis of numerous compounds …

Evolution is the hallmark of life. Descriptions of the evolution of microorganisms have
provided a wealth of information, but knowledge regarding “what happened” has precluded …

Bacterial genomes are remarkably stable from one generation to the next but are plastic on
an evolutionary time scale, substantially shaped by horizontal gene transfer, genome …

Ribozymes are catalytic RNAs with diverse functions including self-splicing and
polymerization. This work aims to discover natural ribozymes that behave as hydrolytic and …

Microbial soil communities are active players in the biogeochemical cycles, impacting soil
fertility and interacting with aboveground organisms. Although soil microbial diversity has …

Covering: 2008 up to 2019 The forces of biochemical adaptive evolution operate at the level
of genes, manifesting in complex phenotypes and the global biodiversity of proteins and …

Bacterial secondary metabolites are widely used as antibiotics, anticancer drugs,
insecticides and food additives. Attempts to engineer their biosynthetic gene clusters (BGCs) …

Polyploidy is common in higher eukaryotes, especially in plants, but it is generally assumed
that most prokaryotes contain a single copy of a circular chromosome and are therefore …

In this review, we discuss applications of the theory of birth-and-death processes to
problems in biology, primarily, those of evolutionary genomics. The mathematical principles …

Bacterial species differ greatly in the number and location of the rRNA operons which may
be present in the bacterial chromosomes and plasmids. Most bacterial species contain more …