Exposure to hypoxia elicits widespread physiological responses that are critical for
successful acclimatization; however, these responses may induce apparent maladaptive …

The study of vascular adaptation to extreme conditions, and in particular to hypoxia,
represents a unique opportunity in cardiovascular physiology, with relevant translational …

Abstract Boos, Christopher John, David R. Woods, Andrea Varias, Sheryl Biscocho, Peter
Heseltine, and Adrian J. Mellor. High altitude and acute mountain sickness and changes in …

Background and aims Exposing the endothelium to acute periods of imposed oscillatory
shear stress reduces endothelial function and elevates circulating microparticles (MPs) …

High-altitude exposure typically reduces endothelial function, and this is modulated by
hemoconcentration resulting from plasma volume contraction. However, the specific impact …

Key points Our objective was to quantify endothelial function (via brachial artery flow‐
mediated dilatation) at sea level (344 m) and high altitude (3800 m) at rest and following …

Intermittent (IH), as opposed to continuous hypoxia (CH), is thought to have beneficial effects
on cardiovascular function and health. In the present study, we examined the acute effects of …

The study of conduit artery endothelial adaptation to hypoxia has been restricted to the
brachial artery, and comparisons with highlanders have been confounded by differences in …

Experimentally induced oscillatory shear stress (OSS) and hypoxia reduce endothelial
function in humans. Acute and sustained hypoxia may cause increases in resting OSS; …

Background HIV infection is an independent risk factor for PAH, but the underlying
pathogenesis remains unclear. ET-1 is a robust vasoconstrictor and key mediator of …