Beyond neutralization: Fc-dependent antibody effector functions in SARS-CoV-2 infection

A Zhang, HD Stacey, MR D'Agostino, Y Tugg… - Nature Reviews …, 2023 - nature.com
Neutralizing antibodies are known to have a crucial role in protecting against SARS-CoV-2
infection and have been suggested to be a useful correlate of protection for vaccine clinical …

Receptor-mediated NETosis on neutrophils

T Chen, Y Li, R Sun, H Hu, Y Liu, M Herrmann… - Frontiers in …, 2021 - frontiersin.org
Neutrophil extracellular traps (NETs), a web-like structures containing chromatin, have a
significant role in assisting the capture and killing of microorganisms by neutrophils during …

Respiratory mucosal delivery of next-generation COVID-19 vaccine provides robust protection against both ancestral and variant strains of SARS-CoV-2

S Afkhami, MR D'Agostino, A Zhang, HD Stacey… - Cell, 2022 - cell.com
The emerging SARS-CoV-2 variants of concern (VOCs) threaten the effectiveness of current
COVID-19 vaccines administered intramuscularly and designed to only target the spike …

[HTML][HTML] The role of NADPH oxidases in infectious and inflammatory diseases

JP Taylor, MT Hubert - Redox biology, 2021 - Elsevier
Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOX) are enzymes that
generate superoxide or hydrogen peroxide from molecular oxygen utilizing NADPH as an …

[HTML][HTML] Role of the humoral immune response during COVID-19: guilty or not guilty?

M Yaugel-Novoa, T Bourlet, S Paul - Mucosal Immunology, 2022 - Elsevier
Systemic and mucosal humoral immune responses are crucial to fight respiratory viral
infections in the current pandemic of COVID-19 caused by the SARS-CoV-2 virus. During …

[HTML][HTML] Protective non-neutralizing SARS-CoV-2 monoclonal antibodies

A Izadi, P Nordenfelt - Trends in immunology, 2024 - cell.com
Recent studies show an important role for non-neutralizing anti-spike antibodies, including
monoclonal antibodies (mAbs), in robustly protecting against SARS-CoV-2 infection. These …

Role of extracellular trap release during bacterial and viral infection

BM Schultz, OA Acevedo, AM Kalergis… - Frontiers in …, 2022 - frontiersin.org
Neutrophils are innate immune cells that play an essential role during the clearance of
pathogens that can release chromatin structures coated by several cytoplasmatic and …

Longitudinal characterization of circulating neutrophils uncovers phenotypes associated with severity in hospitalized COVID-19 patients

TJ LaSalle, ALK Gonye, SS Freeman, P Kaplonek… - Cell Reports …, 2022 - cell.com
Mechanisms of neutrophil involvement in severe coronavirus disease 2019 (COVID-19)
remain incompletely understood. Here, we collect longitudinal blood samples from 306 …

B cell receptor repertoire kinetics after SARS-CoV-2 infection and vaccination

P Kotagiri, F Mescia, WM Rae, L Bergamaschi… - Cell reports, 2022 - cell.com
B cells are important in immunity to both severe acute respiratory syndrome coronavirus-2
(SARS-CoV-2) infection and vaccination, but B cell receptor (BCR) repertoire development …

Neutrophils and influenza: a thin line between helpful and harmful

ST George, J Lai, J Ma, HD Stacey, MS Miller… - Vaccines, 2021 - mdpi.com
Influenza viruses are one of the most prevalent respiratory pathogens known to humans and
pose a significant threat to global public health each year. Annual influenza epidemics are …