Triggering receptor expressed on myeloid cells 2 (TREM2) is a single-pass transmembrane
immune receptor that is mainly expressed on microglia in the brain and macrophages in the …

Alzheimer's disease (AD) is a chronic disabling disease that affects the central nervous
system. The main consequences of AD include the decline of cognitive functions and …

Alzheimer's disease (AD) is the most common form of dementia affecting specifically older
population. AD is an irreversible neurodegenerative CNS disorder associated with complex …

Type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD) commonly co‐occur. T2DM
increases the risk for AD by approximately twofold. Animal models provide one means of …

Chronic exposure to high glucose inside the human body helps in the progression of cancer
by activating various signaling pathways including PI3K, Akt, mTOR, Ras, Raf, MAPK, and …

Alzheimer's disease is the sixth leading cause of death in the United States, and the number
of patients with the disease is set to hit 20 million by 2050. In addition, necroptosis is a form …

Alzheimer's disease (AD) is one of the most devastating brain disorders. Currently, there are
no effective treatments to stop the disease progression and it is becoming a major public …

Central nervous system (CNS) diseases such as Alzheimer's disease (AD), Parkinson's
disease (PD), glioblastoma (GBM), and peripheral nerve injury have been documented as …

In metabolic syndrome, dysregulated signalling activity of the insulin receptor pathway in the
brain due to persistent insulin resistance (IR) condition in the periphery may lead to brain IR …

Obesity is defined as abnormal or excessive fat accumulation that may impair health and is a
risk factor for developing other diseases, such as type 2 diabetes and cardiovascular …