Certain clinical features of schizophrenia, such as working memory disturbances, appear to
emerge from altered gamma oscillatory activity in the prefrontal cortex (PFC). Given the …

Individuals with schizophrenia (SZ) exhibit cognitive performance below expected levels
based on familial cognitive aptitude. One such cognitive process, working memory (WM), is …

Objective: Deficient excitatory drive to parvalbumin-containing cortical interneurons is
proposed as a key neural substrate for altered gamma oscillations and cognitive dysfunction …

Severe infections during pregnancy are one of the major risk factors for cognitive impairment
in the offspring. It has been suggested that maternal inflammation leads to dysfunction of …

Persons with schizophrenia exhibit sensitivity to stress and negative affect (NA), both
strongly correlated with poor functional outcome. This theoretical review suggests that NA …

Whereas cortical GAD67 reduction and subsequent GABA level decrease are consistently
observed in schizophrenia and depression, it remains unclear how these GABAergic …

Dysfunction of prefrontal parvalbumin (PV+) interneurons has been linked with severe
cognitive deficits as observed in several neurodevelopmental disorders including …

GABAergic dysfunctions have been implicated in the pathogenesis of schizophrenia,
especially the associated cognitive impairments. The GABA synthetic enzyme glutamate …

Abnormalities in the γ-aminobutyric acid (GABA) system have been reported in the
postmortem brains of individuals with schizophrenia. In particular, the reduction of one of the …

The electric activities of cortical pyramidal neurons are supported by structurally stable,
morphologically complex axo-dendritic trees. Anatomical differences between axons and …