Classically, the loss of vulnerable neuronal populations in neurodegenerative diseases was
considered to be the consequence of cell autonomous degeneration of neurons. However …

In inflammatory, infectious, ischemic, and neurodegenerative pathologies of th central
nervous system (CNS) glia become “activated” by inflammatory mediators, and express new …

Our objective was to confirm the efficacy and safety of edaravone in amyotrophic lateral
sclerosis (ALS) patients. We conducted a 36-week confirmatory study, consisting of 12-week …

Dendritic cells are potent antigen‐presenting cells that initiate and amplify immune
responses. To determine whether dendritic cells participate in inflammatory reactions in …

Hydrogen sulfide (H2S) is a well‐known cytotoxic gas. Recently it has been shown to
stimulate N‐methyl‐d‐aspartate (NMDA) receptors to enhance long‐term potentiation …

Periventricular leukomalacia (PVL), the major substrate of cerebral palsy in survivors of
prematurity, is defined as focal periventricular necrosis and diffuse gliosis in immature …

Amyotrophic lateral sclerosis (ALS) is a rare disease involving selective and progressive
degeneration and disappearance of motor neurons. Oxidative stress is believed to …

A strong glial reaction typically surrounds the affected upper and lower motor neurons and
degenerating descending tracts of ALS patients. Reactive astrocytes in ALS contain protein …

Neuroinflammation is a pathological hallmark in Parkinson's disease (PD) and amyotrophic
lateral sclerosis (ALS), and is characterized by activated microglia and infiltrating T cells at …

Astrocytes are the most numerous cell type within the central nervous system (CNS) and
perform a variety of tasks, from axon guidance and synaptic support, to the control of the …