Inhibition of the protein kinase mechanistic target of rapamycin (mTOR) with the Food and
Drug Administration (FDA)-approved therapeutic rapamycin promotes health and longevity …

The mechanistic target of rapamycin (mTOR) has gathered significant attention as a
ubiquitously expressed multimeric kinase with key implications for cell growth, proliferation …

Leigh syndrome is a rare, complex, and incurable early onset (typically infant or early
childhood) mitochondrial disorder with both phenotypic and genetic heterogeneity. The …

Mitochondria are small cellular constituents that generate cellular energy (ATP) by oxidative
phosphorylation (OXPHOS). Dysfunction of these organelles is linked to a heterogeneous …

Symmetric, progressive, necrotizing lesions in the brainstem are a defining feature of Leigh
syndrome (LS). A mechanistic understanding of the pathogenesis of these lesions has been …

Background Genetic mitochondrial diseases represent a significant challenge to human
health. These diseases are extraordinarily heterogeneous in clinical presentation and …

Mutations in mitochondrial energy-producing genes lead to a heterogeneous group of
untreatable disorders known as primary mitochondrial diseases (MD). Leigh syndrome (LS) …

Mitochondrial dysfunction caused by aberrant Complex I assembly and reduced activity of
the electron transport chain is pathogenic in many genetic and age-related diseases. Mice …

More than half a century ago, reversible protein phosphorylation was linked to mitochondrial
metabolism through the regulation of pyruvate dehydrogenase. Since this discovery, the …

Mitochondria are cellular organelles critical for numerous cellular processes and harboring
their own circular mitochondrial DNA (mtDNA). Most mtDNA associated disorders (either …