Skeletal tissue is highly innervated. Although different types of nerves have been recently
identified in the bone, the crosstalk between bone and nerves remains unclear. In this …

Abstract Purpose of Review The periosteum, the outer layer of bone, is a major source of
skeletal stem/progenitor cells (SSPCs) for bone repair. Here, we discuss recent findings on …

Abstract Purpose of Review The traditionally understated role of neural regulation in fracture
healing is gaining prominence, as recent findings underscore the peripheral nervous …

Tendons are cable-like connective tissues that transfer both active and passive forces
generated by skeletal muscle to bone. In the mature skeleton, the tendon-bone enthesis is …

Calcitonin gene‐related peptide (CGRP) is a neuropeptide produced by sensory nerves and
functions as a pain sensor. It acts by binding to the calcitonin‐like receptor (CLR, protein; …

Abstract Purpose of Review This review examines the diverse functional relationships that
exist between the peripheral nervous system (PNS) and bone, including key advances over …

Bone is one of the preferential target organs of cancer metastasis. Bone metastasis is
associated with various complications, of which bone pain is most common and debilitating …

Patients with diabetes have a high risk of developing skeletal diseases accompanied by
diabetic peripheral neuropathy (DPN). In this study, we isolated the role of DPN in skeletal …

Over the past decades, emerging evidence in the literature has demonstrated that the
innervation of bone is a crucial modulator for skeletal physiology and pathophysiology. The …

Bone and dental tissues are richly innervated by sensory and sympathetic neurons.
However, the characterization of the morphology, molecular phenotype, and distribution of …