[HTML][HTML] Structural insights into FSP1 catalysis and ferroptosis inhibition

Y Lv, C Liang, Q Sun, J Zhu, H Xu, X Li, Y Li… - Nature …, 2023 - nature.com
Abstract Ferroptosis suppressor protein 1 (FSP1, also known as AIMF2, AMID or PRG3) is a
recently identified glutathione-independent ferroptosis suppressor,–, but its underlying …

[HTML][HTML] AIFM1 beyond cell death: An overview of this OXPHOS-inducing factor in mitochondrial diseases

L Wischhof, E Scifo, D Ehninger, D Bano - EBioMedicine, 2022 - thelancet.com
Apoptosis-inducing factor (AIF) is a mitochondrial intermembrane space flavoprotein with
diverse functions in cellular physiology. In this regard, a large number of studies have …

[HTML][HTML] A genome-wide CRISPR-Cas9 knockout screen identifies FSP1 as the warfarin-resistant vitamin K reductase

DY Jin, X Chen, Y Liu, CM Williams… - Nature …, 2023 - nature.com
Vitamin K is a vital micronutrient implicated in a variety of human diseases. Warfarin, a
vitamin K antagonist, is the most commonly prescribed oral anticoagulant. Patients …

FSP1 oxidizes NADPH to suppress ferroptosis

S Zhang, S Gou, Q Zhang, X Yong, B Gan, D Jia - Cell research, 2023 - nature.com
Dear Editor, Ferroptosis is a form of non-apoptotic cell death characterized by the
accumulation of iron-dependent lipid peroxides and oxidative damage to cell membrane. 1 …

The apoptosis‐inducing factor family: Moonlighting proteins in the crosstalk between mitochondria and nuclei

N Novo, P Ferreira, M Medina - IUBMB life, 2021 - Wiley Online Library
In Homo sapiens, the apoptosis‐inducing factor (AIF) family is represented by three different
proteins, known as AIF, AMID and AIFL, that have in common the mitochondrial localisation …

[HTML][HTML] Impaired AIF-CHCHD4 interaction and mitochondrial calcium overload contribute to auditory neuropathy spectrum disorder in patient-iPSC-derived neurons …

Y Qiu, H Wang, M Fan, H Pan, J Guan, Y Jiang… - Cell Death & …, 2023 - nature.com
Auditory neuropathy spectrum disorder (ANSD) is a hearing impairment caused by
dysfunction of inner hair cells, ribbon synapses, spiral ganglion neurons and/or the auditory …

Molecular characterization of a complex of apoptosis-inducing factor 1 with cytochrome c oxidase of the mitochondrial respiratory chain

JF Hevler, R Zenezeni Chiozzi… - Proceedings of the …, 2021 - National Acad Sciences
Combining mass spectrometry–based chemical cross-linking and complexome profiling, we
analyzed the interactome of heart mitochondria. We focused on complexes of oxidative …

[HTML][HTML] Atomic force microscopy to elicit conformational transitions of ferredoxin-dependent flavin thioredoxin reductases

C Marcuello, GA Frempong, M Balsera, M Medina… - Antioxidants, 2021 - mdpi.com
Flavin and redox-active disulfide domains of ferredoxin-dependent flavin thioredoxin
reductase (FFTR) homodimers should pivot between flavin-oxidizing (FO) and flavin …

[HTML][HTML] FAD/NADH dependent oxidoreductases: from different amino acid sequences to similar protein shapes for playing an ancient function

L Trisolini, N Gambacorta, R Gorgoglione… - Journal of Clinical …, 2019 - mdpi.com
Flavoprotein oxidoreductases are members of a large protein family of specialized
dehydrogenases, which include type II NADH dehydrogenase, pyridine nucleotide …

[HTML][HTML] AIF meets the CHCHD4/Mia40-dependent mitochondrial import pathway

C Reinhardt, G Arena, K Nedara, R Edwards… - … et Biophysica Acta (BBA …, 2020 - Elsevier
In the mitochondria of healthy cells, Apoptosis-Inducing factor (AIF) is required for the
optimal functioning of the respiratory chain machinery, mitochondrial integrity, cell survival …