γδ T cells: origin and fate, subsets, diseases and immunotherapy
Y Hu, Q Hu, Y Li, L Lu, Z Xiang, Z Yin… - … and Targeted Therapy, 2023 - nature.com
The intricacy of diseases, shaped by intrinsic processes like immune system exhaustion and
hyperactivation, highlights the potential of immune renormalization as a promising strategy …
hyperactivation, highlights the potential of immune renormalization as a promising strategy …
[HTML][HTML] Inborn errors of human B cell development, differentiation, and function
SG Tangye, T Nguyen, EK Deenick… - The Journal of …, 2023 - ncbi.nlm.nih.gov
B cells develop from hematopoietic stem cells in the bone marrow. Once generated, they
serve multiple roles in immune regulation and host defense. However, their most important …
serve multiple roles in immune regulation and host defense. However, their most important …
Human MCTS1-dependent translation of JAK2 is essential for IFN-γ immunity to mycobacteria
Human inherited disorders of interferon-gamma (IFN-γ) immunity underlie severe
mycobacterial diseases. We report X-linked recessive MCTS1 deficiency in men with …
mycobacterial diseases. We report X-linked recessive MCTS1 deficiency in men with …
Anti–Interleukin-23 Autoantibodies in Adult-Onset Immunodeficiency
A Cheng, A Kashyap, H Salvator… - … England Journal of …, 2024 - Mass Medical Soc
Background Autoantibodies against interleukin-12 (anti–interleukin-12) are often identified
in patients with thymoma, but opportunistic infections develop in only some of these patients …
in patients with thymoma, but opportunistic infections develop in only some of these patients …
[HTML][HTML] Human inherited CCR2 deficiency underlies progressive polycystic lung disease
AL Neehus, B Carey, M Landekic, P Panikulam… - Cell, 2024 - cell.com
We describe a human lung disease caused by autosomal recessive, complete deficiency of
the monocyte chemokine receptor CC motif chemokine receptor 2 (CCR2). Nine children …
the monocyte chemokine receptor CC motif chemokine receptor 2 (CCR2). Nine children …
Single-cell analysis of psoriasis resolution demonstrates an inflammatory fibroblast state targeted by IL-23 blockade
L Francis, D McCluskey, C Ganier, T Jiang… - Nature …, 2024 - nature.com
Biologic therapies targeting the IL-23/IL-17 axis have transformed the treatment of psoriasis.
However, the early mechanisms of action of these drugs remain poorly understood. Here …
However, the early mechanisms of action of these drugs remain poorly understood. Here …
Interferon-γ and infectious diseases: Lessons and prospects
Infectious diseases continue to claim many lives. Prevention of morbidity and mortality from
these diseases would benefit not just from new medicines and vaccines but also from a …
these diseases would benefit not just from new medicines and vaccines but also from a …
The Th17/IL-17 axis and host defense against fungal infections
SG Tangye, A Puel - The Journal of Allergy and Clinical Immunology: In …, 2023 - Elsevier
Chronic mucocutaneous candidiasis (CMC) was recognized as a primary immunodeficiency
in the early 1970s. However, for almost 40 years, its genetic etiology remained unknown …
in the early 1970s. However, for almost 40 years, its genetic etiology remained unknown …
Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria
Inborn errors of human IFN-γ-dependent macrophagic immunity underlie mycobacterial
diseases, whereas inborn errors of IFN-α/β-dependent intrinsic immunity underlie viral …
diseases, whereas inborn errors of IFN-α/β-dependent intrinsic immunity underlie viral …
Interleukin 23 receptor: Expression and regulation in immune cells
I Mezghiche, H Yahia‐Cherbal… - European Journal of …, 2024 - Wiley Online Library
The importance of IL‐23 and its specific receptor, IL‐23R, in the pathogenesis of several
chronic inflammatory diseases has been established, but the underlying pathological …
chronic inflammatory diseases has been established, but the underlying pathological …