The intricacy of diseases, shaped by intrinsic processes like immune system exhaustion and
hyperactivation, highlights the potential of immune renormalization as a promising strategy …

B cells develop from hematopoietic stem cells in the bone marrow. Once generated, they
serve multiple roles in immune regulation and host defense. However, their most important …

Human inherited disorders of interferon-gamma (IFN-γ) immunity underlie severe
mycobacterial diseases. We report X-linked recessive MCTS1 deficiency in men with …

Background Autoantibodies against interleukin-12 (anti–interleukin-12) are often identified
in patients with thymoma, but opportunistic infections develop in only some of these patients …

We describe a human lung disease caused by autosomal recessive, complete deficiency of
the monocyte chemokine receptor CC motif chemokine receptor 2 (CCR2). Nine children …

Biologic therapies targeting the IL-23/IL-17 axis have transformed the treatment of psoriasis.
However, the early mechanisms of action of these drugs remain poorly understood. Here …

Infectious diseases continue to claim many lives. Prevention of morbidity and mortality from
these diseases would benefit not just from new medicines and vaccines but also from a …

Chronic mucocutaneous candidiasis (CMC) was recognized as a primary immunodeficiency
in the early 1970s. However, for almost 40 years, its genetic etiology remained unknown …

Inborn errors of human IFN-γ-dependent macrophagic immunity underlie mycobacterial
diseases, whereas inborn errors of IFN-α/β-dependent intrinsic immunity underlie viral …

The importance of IL‐23 and its specific receptor, IL‐23R, in the pathogenesis of several
chronic inflammatory diseases has been established, but the underlying pathological …