Progenitor cells in diseased human liver

TA Roskams, L Libbrecht… - Seminars in liver …, 2003 - thieme-connect.com
Hepatic progenitor cells are immature epithelial cells that reside in the smallest ramifications
of the biliary tree in human liver. These cells are capable of differentiating toward the biliary …

Hepatic stem cells in liver regeneration

SS Thorgeirsson - The FASEB Journal, 1996 - Wiley Online Library
The concept that the liver contains epithelial cells that share some of the major properties of
stem cells of the well‐characterized, stem cell‐fed lineages found in bone marrow, intestinal …

Wnt/β-catenin signaling contributes to activation of normal and tumorigenic liver progenitor cells

W Yang, HX Yan, L Chen, Q Liu, YQ He, LX Yu… - Cancer research, 2008 - AACR
Adult hepatic progenitor (oval) cells are facultative stem cells in liver, which participate in a
range of human liver diseases, including hepatocellular carcinoma (HCC). However, the …

Keratin 19 as a biochemical marker of skin stem cells in vivo and in vitro: keratin 19 expressing cells are differentially localized in function of anatomic sites, and their …

M Michel, N Török, M Josée Godbout… - Journal of cell …, 1996 - journals.biologists.com
This study was undertaken to evaluate keratin 19 (K19) as a biochemical marker for skin
stem cells in order to address some long standing questions concerning these cells in the …

The origin and liver repopulating capacity of murine oval cells

X Wang, M Foster, M Al-Dhalimy… - Proceedings of the …, 2003 - National Acad Sciences
The appearance of bipotential oval cells in chronic liver injury suggests the existence of
hepatocyte progenitor/stem cells. To study the origin and properties of this cell population …

[PDF][PDF] Hepatic oval cells express the hematopoietic stem cell marker Thy‐1 in the rat

BE Petersen, JP Goff, JS Greenberger… - …, 1998 - Wiley Online Library
Hepatic oval cells (HOC) are a small subpopulation of cells found in the liver when
hepatocyte proliferation is inhibited and followed by some type of hepatic injury. HOC can be …

In Vivo Differentiation of Rat Liver Oval Cells into Hepatocytes

RP Evarts, P Nagy, H Nakatsukasa, E Marsden… - Cancer research, 1989 - AACR
Abstract The Solt-Farber protocol, in the absence of an initiating agent, was used to examine
the precursor-product relationship between oval cells and hepatocytes in rat liver. The …

Generation and characterization of p53 null transformed hepatic progenitor cells: oval cells give rise to hepatocellular carcinoma

ML Dumble, EJ Croager, GCT Yeoh, EA Quail - Carcinogenesis, 2002 - academic.oup.com
Oval cells are bipotential liver stem cells able to differentiate into hepatocytes and bile duct
epithelia. In normal adult liver oval cells are quiescent, existing in low numbers around the …

[PDF][PDF] Mouse A6–positive hepatic oval cells also express several hematopoietic stem cell markers

BE Petersen, B Grossbard, H Hatch, L Pi, J Deng… - …, 2003 - Wiley Online Library
Hepatic oval cells (HOC) are thought to be a type of facultative stem cell that arises as a
result of certain forms of hepatic injury. A new and more efficient model has been …

Evidence for the stem cell origin of hepatocellular carcinoma and cholangiocarcinoma.

S Sell, HA Dunsford - The American journal of pathology, 1989 - ncbi.nlm.nih.gov
A review of the morphologic, autoradiographic, and phenotypic analysis of the cellular
changes seen during induction of cancer of the liver in rats by chemical carcinogens is used …