Ultrasound-based micro-/nanosystems for biomedical applications

H Huang, Y Zheng, M Chang, J Song, L Xia… - Chemical …, 2024 - ACS Publications
Due to the intrinsic non-invasive nature, cost-effectiveness, high safety, and real-time
capabilities, besides diagnostic imaging, ultrasound as a typical mechanical wave has been …

A sound approach to advancing healthcare systems: the future of biomedical acoustics

J Rufo, P Zhang, R Zhong, LP Lee, TJ Huang - Nature Communications, 2022 - nature.com
Newly developed acoustic technologies are playing a transformational role in life science
and biomedical applications ranging from the activation and inactivation of …

Current state of potential mechanisms supporting low intensity focused ultrasound for neuromodulation

J Dell'Italia, JL Sanguinetti, MM Monti… - Frontiers in human …, 2022 - frontiersin.org
Low intensity focused ultrasound (LIFU) has been gaining traction as a non-invasive
neuromodulation technology due to its superior spatial specificity relative to transcranial …

Modulation of deep neural circuits with sonogenetics

Q Xian, Z Qiu, S Murugappan, S Kala… - Proceedings of the …, 2023 - National Acad Sciences
Noninvasive control of neuronal activity in the deep brain can be illuminating for probing
brain function and treating dysfunctions. Here, we present a sonogenetic approach for …

Ultrasound-mediated spatial and temporal control of engineered cells in vivo

F Ivanovski, M Meško, T Lebar, M Rupnik… - Nature …, 2024 - nature.com
Remote regulation of cells in deep tissue remains a significant challenge. Low-intensity
pulsed ultrasound offers promise for in vivo therapies due to its non-invasive nature and …

Ultrasound-Induced Cascade Amplification in a Mechanoluminescent Nanotransducer for Enhanced Sono-Optogenetic Deep Brain Stimulation

W Wang, KW Kevin Tang, I Pyatnitskiy, X Liu, X Shi… - ACS …, 2023 - ACS Publications
Remote and genetically targeted neuromodulation in the deep brain is important for
understanding and treatment of neurological diseases. Ultrasound-triggered …

Mechanical stimulation and electrophysiological monitoring at subcellular resolution reveals differential mechanosensation of neurons within networks

KC Kasuba, AP Buccino, J Bartram, BM Gaub… - Nature …, 2024 - nature.com
A growing consensus that the brain is a mechanosensitive organ is driving the need for tools
that mechanically stimulate and simultaneously record the electrophysiological response of …

On closed-loop brain stimulation systems for improving the quality of life of patients with neurological disorders

AN Belkacem, N Jamil, S Khalid… - Frontiers in human …, 2023 - frontiersin.org
Emerging brain technologies have significantly transformed human life in recent decades.
For instance, the closed-loop brain-computer interface (BCI) is an advanced software …

Transcranial Nongenetic Neuromodulation via Bioinspired Vesicle‐Enabled Precise NIR‐II Optical Stimulation

Y Zhang, D Yang, J Nie, J Dai, H Wu… - Advanced …, 2023 - Wiley Online Library
Regulating the activity of specific neurons is essentially important in neurocircuit dissection
and neuropathy therapy. As a recently developed strategy, nanomaterial‐enabled …

[HTML][HTML] Sonogenetics: recent advances and future directions

T Liu, MH Choi, J Zhu, T Zhu, J Yang, N Li, Z Chen… - Brain Stimulation, 2022 - Elsevier
Sonogenetics refers to the use of genetically encoded, ultrasound-responsive mediators for
noninvasive and selective control of neural activity. It is a promising tool for studying neural …