Microneedle array systems for long-acting drug delivery

LK Vora, K Moffatt, IA Tekko, AJ Paredes… - European Journal of …, 2021 - Elsevier
The development of microneedles (MNs) assisted drug delivery technologies have been
highly active for more than two decades. The minimally invasive and self-administered MN …

Nanocrystals as a master key to deliver hydrophobic drugs via multiple administration routes

MB McGuckin, J Wang, R Ghanma, N Qin… - Journal of Controlled …, 2022 - Elsevier
The poor aqueous solubility of many approved drugs and most new chemical entities poses
a challenge to drug delivery scientists working in academic and industrial labs. Despite the …

Dissolving microneedle-mediated dermal delivery of itraconazole nanocrystals for improved treatment of cutaneous candidiasis

AD Permana, AJ Paredes, F Volpe-Zanutto… - European Journal of …, 2020 - Elsevier
The administration of conventional dosage forms of itraconazole (ITZ) for cutaneous
candidiasis treatment is limited by its poor aqueous solubility and the deep location of …

Bioavailability enhancement of poorly water-soluble drugs via nanocomposites: Formulation–Processing aspects and challenges

A Bhakay, M Rahman, RN Dave, E Bilgili - Pharmaceutics, 2018 - mdpi.com
Drug nanoparticles embedded in a dispersant matrix as a secondary phase, ie, drug-laden
nanocomposites, offer a versatile delivery platform for enhancing the dissolution rate and …

Albendazole nanocrystal-based dissolving microneedles with improved pharmacokinetic performance for enhanced treatment of cystic echinococcosis

AD Permana, AJ Paredes, FV Zanutto… - … Applied Materials & …, 2021 - ACS Publications
Cystic echinococcosis (CE) is a zoonosis caused by Echinococcus spp., affecting both
humans and animals' lives. Current treatment of CE by oral administration of albendazole …

Microarray patches: breaking down the barriers to contraceptive care and HIV prevention for women across the globe

AJ Paredes, IK Ramöller, PE McKenna… - Advanced Drug Delivery …, 2021 - Elsevier
Despite the existence of a variety of contraceptive products for women, as well as decades
of research into the prevention and treatment of human immunodeficiency virus (HIV), there …

[HTML][HTML] Synthesis and characterization of mesoporous SBA-15 and SBA-16 as carriers to improve albendazole dissolution rate

ME Adrover, M Pedernera, M Bonne, B Lebeau… - Saudi Pharmaceutical …, 2020 - Elsevier
Albendazole (ABZ, anti-parasitic active pharmaceutical ingredient) is a crystalline low water-
soluble drug, thus the dissolution rate in gastrointestinal fluids is limited. Consequently, the …

Nanocrystal-based 3D-printed tablets: Semi-solid extrusion using melting solidification printing process (MESO-PP) for oral administration of poorly soluble drugs

L Lopez-Vidal, JP Real, DA Real, N Camacho… - International journal of …, 2022 - Elsevier
This is the first report on the inclusion of nanocrystals (NCs) within 3D-printed oral solid
dosage forms–3D-printed tablets or printlets–produced by the Melting Solidification Printing …

[HTML][HTML] Anthelmintics for drug repurposing: Opportunities and challenges

SE Alavi, HE Shahmabadi - Saudi Pharmaceutical Journal, 2021 - Elsevier
Drug repositioning is defined as a process to identify a new application for drugs. This
approach is critical as it takes advantage of well-known pharmacokinetics …

Chitosan coated nanostructured lipid carriers for enhanced in vivo efficacy of albendazole against Trichinella spiralis

RK Eid, DS Ashour, EA Essa, GM El Maghraby… - Carbohydrate …, 2020 - Elsevier
The study investigated chitosan coated nanostructured lipid carriers (NLCs) for oral delivery
of albendazole in treatment of trichinellosis. NLCs comprised precirol and oleic acid with …