Microneedle array systems for long-acting drug delivery
The development of microneedles (MNs) assisted drug delivery technologies have been
highly active for more than two decades. The minimally invasive and self-administered MN …
highly active for more than two decades. The minimally invasive and self-administered MN …
Nanocrystals as a master key to deliver hydrophobic drugs via multiple administration routes
MB McGuckin, J Wang, R Ghanma, N Qin… - Journal of Controlled …, 2022 - Elsevier
The poor aqueous solubility of many approved drugs and most new chemical entities poses
a challenge to drug delivery scientists working in academic and industrial labs. Despite the …
a challenge to drug delivery scientists working in academic and industrial labs. Despite the …
Dissolving microneedle-mediated dermal delivery of itraconazole nanocrystals for improved treatment of cutaneous candidiasis
The administration of conventional dosage forms of itraconazole (ITZ) for cutaneous
candidiasis treatment is limited by its poor aqueous solubility and the deep location of …
candidiasis treatment is limited by its poor aqueous solubility and the deep location of …
Bioavailability enhancement of poorly water-soluble drugs via nanocomposites: Formulation–Processing aspects and challenges
Drug nanoparticles embedded in a dispersant matrix as a secondary phase, ie, drug-laden
nanocomposites, offer a versatile delivery platform for enhancing the dissolution rate and …
nanocomposites, offer a versatile delivery platform for enhancing the dissolution rate and …
Albendazole nanocrystal-based dissolving microneedles with improved pharmacokinetic performance for enhanced treatment of cystic echinococcosis
Cystic echinococcosis (CE) is a zoonosis caused by Echinococcus spp., affecting both
humans and animals' lives. Current treatment of CE by oral administration of albendazole …
humans and animals' lives. Current treatment of CE by oral administration of albendazole …
Microarray patches: breaking down the barriers to contraceptive care and HIV prevention for women across the globe
AJ Paredes, IK Ramöller, PE McKenna… - Advanced Drug Delivery …, 2021 - Elsevier
Despite the existence of a variety of contraceptive products for women, as well as decades
of research into the prevention and treatment of human immunodeficiency virus (HIV), there …
of research into the prevention and treatment of human immunodeficiency virus (HIV), there …
[HTML][HTML] Synthesis and characterization of mesoporous SBA-15 and SBA-16 as carriers to improve albendazole dissolution rate
ME Adrover, M Pedernera, M Bonne, B Lebeau… - Saudi Pharmaceutical …, 2020 - Elsevier
Albendazole (ABZ, anti-parasitic active pharmaceutical ingredient) is a crystalline low water-
soluble drug, thus the dissolution rate in gastrointestinal fluids is limited. Consequently, the …
soluble drug, thus the dissolution rate in gastrointestinal fluids is limited. Consequently, the …
Nanocrystal-based 3D-printed tablets: Semi-solid extrusion using melting solidification printing process (MESO-PP) for oral administration of poorly soluble drugs
This is the first report on the inclusion of nanocrystals (NCs) within 3D-printed oral solid
dosage forms–3D-printed tablets or printlets–produced by the Melting Solidification Printing …
dosage forms–3D-printed tablets or printlets–produced by the Melting Solidification Printing …
[HTML][HTML] Anthelmintics for drug repurposing: Opportunities and challenges
SE Alavi, HE Shahmabadi - Saudi Pharmaceutical Journal, 2021 - Elsevier
Drug repositioning is defined as a process to identify a new application for drugs. This
approach is critical as it takes advantage of well-known pharmacokinetics …
approach is critical as it takes advantage of well-known pharmacokinetics …
Chitosan coated nanostructured lipid carriers for enhanced in vivo efficacy of albendazole against Trichinella spiralis
The study investigated chitosan coated nanostructured lipid carriers (NLCs) for oral delivery
of albendazole in treatment of trichinellosis. NLCs comprised precirol and oleic acid with …
of albendazole in treatment of trichinellosis. NLCs comprised precirol and oleic acid with …