Components of transcriptional machinery are selectively partitioned into specific
condensates, often mediated by protein disorder, yet we know little about how this specificity …

The transcriptional machinery is thought to dissociate from DNA during replication. Certain
proteins, termed epigenetic marks, must be transferred from parent to daughter DNA strands …

During development, cells make switch-like decisions to activate new gene programs
specifying cell lineage. The mechanisms underlying these decisive choices remain unclear …

Cyclin-dependent kinases (CDKs) are presumed to control the cell cycle by phosphorylating
a large number of proteins involved in S-phase and mitosis, two mechanistically disparate …

The term “biomolecular condensates” is used to describe membraneless compartments in
eukaryotic cells, accumulating proteins and nucleic acids. Biomolecular condensates are …

Eukaryotic DNA replication begins with the loading of the MCM replicative DNA helicase as
a head-to-head double hexamer at origins of DNA replication,–. Our current understanding …

Type II topoisomerases modulate chromosome supercoiling, condensation, and catenation
by moving one double-stranded DNA segment through a transient break in a second duplex …

In eukaryotes, the origin recognition complex (ORC) faciliates the assembly of pre-
replicative complex (pre-RC) at origin DNA for replication licensing. Here we show that the N …

The loading of the bacterial replicative helicase DnaB is an essential step for genome
replication and depends on the assistance of accessory proteins. Several of these proteins …

The first step toward eukaryotic genome duplication is loading of the replicative helicase
onto chromatin. This 'licensing'step initiates with the recruitment of the origin recognition …