Polycystic ovary syndrome (PCOS) affects 5–20% of women of reproductive age worldwide.
The condition is characterized by hyperandrogenism, ovulatory dysfunction and polycystic …

Polycystic ovary syndrome (PCOS) was hypothesized to result from functional ovarian
hyperandrogenism (FOH) due to dysregulation of androgen secretion in 1989–1995 …

BACKGROUND Androgens, FSH, anti-Müllerian hormone (AMH) and estradiol (E2) are
essential in human ovarian folliculogenesis. However, the interactions between these four …

Although hormonal regulation of ovarian follicle development has been extensively
investigated, most studies concentrate on the development of early antral follicles to the …

BACKGROUND In women, anti-Müllerian hormone (AMH) is exclusively produced by
granulosa cells of ovarian follicles during the early stages of follicle development. After an …

The definition presented here represents the first realistic attempt by the scientific community
to standardize the definition of poor ovarian response (POR) in a simple and reproducible …

BACKGROUND The main objective of individualization of treatment in IVF is to offer every
single woman the best treatment tailored to her own unique characteristics, thus maximizing …

Mammalian eggs (oocytes) are formed during fetal life and establish associations with
somatic cells to form primordial follicles that create a store of germ cells (the primordial pool) …

Menopause is the final step in the process referred to as ovarian ageing. The age related
decrease in follicle numbers dictates the onset of cycle irregularity and the final cessation of …

BACKGROUND Ovarian follicles undergo dynamic morphologic and endocrinologic
changes during the human menstrual cycle. The physiologic mechanisms underlying …