Overcoming resistance to selective serotonin reuptake inhibitors: targeting serotonin, serotonin-1A receptors and adult neuroplasticity
F Vahid-Ansari, M Zhang, A Zahrai… - Frontiers in …, 2019 - frontiersin.org
Major depressive disorder (MDD) is the most prevalent mental illness contributing to global
disease burden. Selective serotonin (5-HT) reuptake inhibitors (SSRIs) are the first-line …
disease burden. Selective serotonin (5-HT) reuptake inhibitors (SSRIs) are the first-line …
Rat dams exposed repeatedly to a daily brief separation from the pups exhibit increased maternal behavior, decreased anxiety and altered levels of receptors for …
In the present study we investigated the neurobiological mechanisms underlying expression
of maternal behavior. Increased maternal behavior was experimentally induced by a brief 15 …
of maternal behavior. Increased maternal behavior was experimentally induced by a brief 15 …
Repeated systemic treatment with rapamycin affects behavior and amygdala protein expression in rats
M Hadamitzky, A Herring, J Kirchhof… - International Journal …, 2018 - academic.oup.com
Background Clinical data indicate that therapy with small-molecule immunosuppressive
drugs is frequently accompanied by an incidence rate of neuropsychiatric symptoms. In the …
drugs is frequently accompanied by an incidence rate of neuropsychiatric symptoms. In the …
Anxiolytic effect of fatty acids and terpenes fraction from Aloysia triphylla: Serotoninergic, GABAergic and glutamatergic implications
E Jiménez-Ferrer, MA Santillán-Urquiza… - Biomedicine & …, 2017 - Elsevier
Aloysia triphylla (Verbenaceae) is an aromatic medicinal plant, and it is used for the
treatment of “nervous” problems as,“sadness” and “nervousness”. While, there are no …
treatment of “nervous” problems as,“sadness” and “nervousness”. While, there are no …
Effects of acute or repeated paroxetine and fluoxetine treatment on affective behavior in male and female adolescent rats
LR Amodeo, VY Greenfield, DE Humphrey… - …, 2015 - Springer
Rationale The SSRI antidepressant fluoxetine is one of the few drugs that is effective at
treating depression in adolescent humans. In contrast, the SSRI paroxetine has limited …
treating depression in adolescent humans. In contrast, the SSRI paroxetine has limited …
Withdrawal from brief repeated alcohol treatment in adolescent and adult male and female rats
W Fleming, Q Jones, U Chandra, A Saini… - Alcoholism: clinical …, 2019 - Wiley Online Library
Background Early initiation of alcohol drinking has been associated with increased risk of
alcohol dependence in adulthood. Although negative affect mediated in part by corticotropin …
alcohol dependence in adulthood. Although negative affect mediated in part by corticotropin …
Brief social isolation in the adolescent Wistar-Kyoto rat model of endogenous depression alters corticosterone and regional monoamine concentrations
RA Shetty, M Sadananda - Neurochemical research, 2017 - Springer
Abstract The Wistar-Kyoto rat (WKY) model has been suggested as a model of adult and
adolescent depression though face, predictive and construct validities of the model to …
adolescent depression though face, predictive and construct validities of the model to …
[HTML][HTML] 5-HT1A receptor-mediated activation of neuroendocrine responses and multiple protein kinase pathways in the peripubertal rat hypothalamus
ML Petrunich-Rutherford, F Garcia, G Battaglia - Neuropharmacology, 2018 - Elsevier
Increasing evidence suggests that multiple factors can produce effects on the immature
brain that are distinct and more long-lasting than those produced in adults. The …
brain that are distinct and more long-lasting than those produced in adults. The …
A comparison of the anxiolytic and hypnotic effects of Origanum majorana essential oil and alprazolam in male mice
N Manouchehri, S Abbasi-Maleki… - Herbal Medicines Journal …, 2019 - hmj.lums.ac.ir
Background and Aim: Previous studies have reported many pharmacological properties for
Origanum majorana, including anticonvulsant, analgesic, sedative, and antidepressant-like …
Origanum majorana, including anticonvulsant, analgesic, sedative, and antidepressant-like …
Contrasting regional Fos expression in adolescent and young adult rats following acute administration of the antidepressant paroxetine
Adolescents and adults may respond differently to antidepressants, with poorer efficacy and
greater probability of adverse effects in adolescents. The mechanisms underlying this …
greater probability of adverse effects in adolescents. The mechanisms underlying this …