Liquid biopsy enters the clinic—implementation issues and future challenges

M Ignatiadis, GW Sledge, SS Jeffrey - Nature reviews Clinical oncology, 2021 - nature.com
Historically, studies of disseminated tumour cells in bone marrow and circulating tumour
cells in peripheral blood have provided crucial insights into cancer biology and the …

[HTML][HTML] Recommendations for a practical implementation of circulating tumor DNA mutation testing in metastatic non-small-cell lung cancer

E Heitzer, D Van Den Broek, MG Denis, P Hofman… - ESMO open, 2022 - Elsevier
Background Liquid biopsy (LB) is a rapidly evolving diagnostic tool for precision oncology
that has recently found its way into routine practice as an adjunct to tissue biopsy (TB). The …

Single-molecule amplification-free multiplexed detection of circulating microRNA cancer biomarkers from serum

S Cai, T Pataillot-Meakin, A Shibakawa, R Ren… - Nature …, 2021 - nature.com
MicroRNAs (miRNAs) play essential roles in post-transcriptional gene expression and are
also found freely circulating in bodily fluids such as blood. Dysregulated miRNA signatures …

Multimodal analysis of cell-free DNA whole-genome sequencing for pediatric cancers with low mutational burden

P Peneder, AM Stütz, D Surdez, M Krumbholz… - Nature …, 2021 - nature.com
Sequencing of cell-free DNA in the blood of cancer patients (liquid biopsy) provides
attractive opportunities for early diagnosis, assessment of treatment response, and minimally …

Detection of diagnostic and prognostic methylation-based signatures in liquid biopsy specimens from patients with meningiomas

GA Herrgott, JM Snyder, R She, TM Malta… - Nature …, 2023 - nature.com
Recurrence of meningiomas is unpredictable by current invasive methods based on
surgically removed specimens. Identification of patients likely to recur using noninvasive …

Targeted analysis of cell-free circulating tumor DNA is suitable for early relapse and actionable target detection in patients with neuroblastoma

M Lodrini, J Graef, TM Thole-Kliesch… - Clinical Cancer …, 2022 - AACR
Purpose: Treating refractory or relapsed neuroblastoma remains challenging. Monitoring
body fluids for tumor-derived molecular information indicating minimal residual disease …

Detection of clinical progression through plasma ctDNA in metastatic melanoma patients: a comparison to radiological progression

G Marsavela, AC McEvoy, MR Pereira, AL Reid… - British journal of …, 2022 - nature.com
Background The validity of circulating tumour DNA (ctDNA) as an indicator of disease
progression compared to medical imaging in patients with metastatic melanoma requires …

Combinatorial power of cfDNA, CTCs and EVs in oncology

C Keup, R Kimmig, S Kasimir-Bauer - Diagnostics, 2022 - mdpi.com
Liquid biopsy is a promising technique for clinical management of oncological patients. The
diversity of analytes circulating in the blood useable for liquid biopsy testing is enormous …

Consensus recommendations to optimize testing for new targetable alterations in non-small cell lung cancer

DN Ionescu, TL Stockley, S Banerji, C Couture… - Current …, 2022 - mdpi.com
Non-small cell lung cancer (NSCLC) has historically been associated with a poor prognosis
and low 5-year survival, but the use of targeted therapies in NSCLC has improved patient …

Liquid biopsy for early diagnosis of non-small cell lung carcinoma: recent research and detection technologies

L Chang, J Li, R Zhang - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2022 - Elsevier
Liquid biopsy, an innovative method for early diagnosis of cancer, has changed the
traditional method of diagnosing lung cancer and is considered a feasible auxiliary …