Due to advances in chronobiology, chronopharmacology, and global market constraints, the
traditional goal of pharmaceutics (eg design drug delivery systems with a constant drug …

The development of control-relevant models for a variety of biomedical engineering drug
delivery problems is reviewed in this paper. A summary of each control problem is followed …

From the Publisher: This objective, referenced collection of over 300 articles will cover every
aspect of medical devices and instrumentation in four volumes, totalling about 3,000 pages …

The development of an artificial pancreas is placed in the context of the history of the field of
feedback control systems, beginning with the water clock of ancient Greece, and including a …

We are witnessing a notable rise in the translational use of information technology and
control systems engineering tools in clinical practice. This paper empowers the computer …

In this paper, the potential applications of control technology to clinical pharmacology are
discussed, specifically the control of drug dosing. The use of closed-loop control for clinical …

An advanced model-based control technique for regulating the blood glucose for patients
with Type 1 diabetes is presented. The optimal insulin delivery rate is obtained off-line as an …

The purpose of the paper is to extend dynamic matrix control (DMC) to handle different
operating regimes and to reject parameter disturbances. This is done by two new multiple …

A model-based control methodology was developed for automated regulation of mean
arterial pressure and cardiac output in critical care subjects using inotropic and vasoactive …

Fractional calculus has been opening new doors in terms of better modeling and control of
several phenomena and processes. Biomedical engineering has seen a lot of combined …