We report the sequences of 1,244 human Y chromosomes randomly ascertained from 26
worldwide populations by the 1000 Genomes Project. We discovered more than 65,000 …

Pathogens have always been a major cause of human mortality, so they impose strong
selective pressure on the human genome. Data from population genetic studies, including …

Structural variants (SVs) rearrange large segments of DNA and can have profound
consequences in evolution and human disease,. As national biobanks, disease-association …

The cancer genome is moulded by the dual processes of somatic mutation and selection.
Homozygous deletions in cancer genomes occur over recessive cancer genes, where they …

Copy number variants (CNVs) were the subject of extensive research in the past years. They
are common features of the human genome that play an important role in evolution …

Following the domestication of maize over the past∼ 10,000 years, breeders have exploited
the extensive genetic diversity of this species to mold its phenotype to meet human needs …

Duplications are the primary force by which new gene functions arise and provide a
substrate for large-scale structural variation. Analysis of thousands of genomes shows that …

Genomic structural variation is an important and abundant source of genetic and phenotypic
variation. Here, we describe the first systematic and genome-wide analysis of copy number …

Individuals of the same species are generally thought to have very similar genomes.
However, there is growing evidence that structural variation in the form of copy number …

Understanding human-specific patterns of brain gene expression and regulation can
provide key insights into human brain evolution and speciation. Here, we use next …