Punctuated bursts in human male demography inferred from 1,244 worldwide Y-chromosome sequences
We report the sequences of 1,244 human Y chromosomes randomly ascertained from 26
worldwide populations by the 1000 Genomes Project. We discovered more than 65,000 …
worldwide populations by the 1000 Genomes Project. We discovered more than 65,000 …
From evolutionary genetics to human immunology: how selection shapes host defence genes
LB Barreiro, L Quintana-Murci - Nature Reviews Genetics, 2010 - nature.com
Pathogens have always been a major cause of human mortality, so they impose strong
selective pressure on the human genome. Data from population genetic studies, including …
selective pressure on the human genome. Data from population genetic studies, including …
A structural variation reference for medical and population genetics
Structural variants (SVs) rearrange large segments of DNA and can have profound
consequences in evolution and human disease,. As national biobanks, disease-association …
consequences in evolution and human disease,. As national biobanks, disease-association …
Signatures of mutation and selection in the cancer genome
GR Bignell, CD Greenman, H Davies, AP Butler… - Nature, 2010 - nature.com
The cancer genome is moulded by the dual processes of somatic mutation and selection.
Homozygous deletions in cancer genomes occur over recessive cancer genes, where they …
Homozygous deletions in cancer genomes occur over recessive cancer genes, where they …
[HTML][HTML] DNA copy number variation: Main characteristics, evolutionary significance, and pathological aspects
Copy number variants (CNVs) were the subject of extensive research in the past years. They
are common features of the human genome that play an important role in evolution …
are common features of the human genome that play an important role in evolution …
Maize inbreds exhibit high levels of copy number variation (CNV) and presence/absence variation (PAV) in genome content
Following the domestication of maize over the past∼ 10,000 years, breeders have exploited
the extensive genetic diversity of this species to mold its phenotype to meet human needs …
the extensive genetic diversity of this species to mold its phenotype to meet human needs …
Human adaptation and evolution by segmental duplication
MY Dennis, EE Eichler - Current opinion in genetics & development, 2016 - Elsevier
Duplications are the primary force by which new gene functions arise and provide a
substrate for large-scale structural variation. Analysis of thousands of genomes shows that …
substrate for large-scale structural variation. Analysis of thousands of genomes shows that …
Analysis of copy number variations among diverse cattle breeds
Genomic structural variation is an important and abundant source of genetic and phenotypic
variation. Here, we describe the first systematic and genome-wide analysis of copy number …
variation. Here, we describe the first systematic and genome-wide analysis of copy number …
Pervasive gene content variation and copy number variation in maize and its undomesticated progenitor
RA Swanson-Wagner, SR Eichten, S Kumari… - Genome …, 2010 - genome.cshlp.org
Individuals of the same species are generally thought to have very similar genomes.
However, there is growing evidence that structural variation in the form of copy number …
However, there is growing evidence that structural variation in the form of copy number …
Human-specific transcriptional networks in the brain
G Konopka, T Friedrich, J Davis-Turak, K Winden… - Neuron, 2012 - cell.com
Understanding human-specific patterns of brain gene expression and regulation can
provide key insights into human brain evolution and speciation. Here, we use next …
provide key insights into human brain evolution and speciation. Here, we use next …