Ruthenium complexes as anticancer agents: A brief history and perspectives
SY Lee, CY Kim, TG Nam - Drug design, development and therapy, 2020 - Taylor & Francis
Platinum (Pt)-based anticancer drugs such as cisplatin have been used to treat various
cancers. However, they have some limitations including poor selectivity and toxicity towards …
cancers. However, they have some limitations including poor selectivity and toxicity towards …
The development of anticancer ruthenium (II) complexes: from single molecule compounds to nanomaterials
Cancer is rapidly becoming the top killer in the world. Most of the FDA approved anticancer
drugs are organic molecules, while metallodrugs are very scarce. The advent of the first …
drugs are organic molecules, while metallodrugs are very scarce. The advent of the first …
Ru (II) compounds: next-generation anticancer metallotherapeutics?
Metal based therapeutics are a precious class of drugs in oncology research that include
examples of theranostic drugs, which are active in both diagnostic, specifically imaging, and …
examples of theranostic drugs, which are active in both diagnostic, specifically imaging, and …
Synthesis and Structure of Arene Ru(II) N∧O-Chelating Complexes: In Vitro Cytotoxicity and Cancer Cell Death Mechanism
A panel of six new structurally related organometallic arene Ru (II) complexes of general
composition [(η6-benzene) Ru (L) Cl](1–3) and [(η6-p-cymene) Ru (L) Cl](4–6)(L …
composition [(η6-benzene) Ru (L) Cl](1–3) and [(η6-p-cymene) Ru (L) Cl](4–6)(L …
An overview of advancement of organoruthenium (II) complexes as prospective anticancer agents
The successful clinical translation of platinum drugs for cancer treatment has witnessed an
upsurge in the development of metal compounds as therapeutics and diagnostics drugs …
upsurge in the development of metal compounds as therapeutics and diagnostics drugs …
Design concepts of half-sandwich organoruthenium anticancer agents based on bidentate bioactive ligands
The small molecule anticancer agent cisplatin and its Pt (II) analogs carboplatin and
oxaliplatin are widely used to treat a variety of tumorigenic diseases. Despite their structural …
oxaliplatin are widely used to treat a variety of tumorigenic diseases. Despite their structural …
Ruthenium (II) arene complexes containing benzhydrazone ligands: synthesis, structure and antiproliferative activity
MKM Subarkhan, R Ramesh - Inorganic Chemistry Frontiers, 2016 - pubs.rsc.org
A suitable method for the synthesis of ruthenium (II) arene benzhydrazone complexes (1–6)
of the general formula [(η6-arene) Ru (L) Cl](arene-benzene or p-cymene; L-monobasic …
of the general formula [(η6-arene) Ru (L) Cl](arene-benzene or p-cymene; L-monobasic …
Synthesis and molecular structure of arene ruthenium (II) benzhydrazone complexes: impact of substitution at the chelating ligand and arene moiety on …
MKM Subarkhan, R Ramesh, Y Liu - New Journal of Chemistry, 2016 - pubs.rsc.org
A convenient method for the synthesis of ruthenium (II) arene benzhydrazone complexes (1–
6) of the general formula [(η6-arene) Ru (L) Cl](arene-benzene or p-cymene; L-monobasic …
6) of the general formula [(η6-arene) Ru (L) Cl](arene-benzene or p-cymene; L-monobasic …
Recent advances in acylpyrazolone metal complexes and their potential applications
This review is aimed at updating the current advance of metal complexes bearing
acylpyrazolonate ligands. Novel synthetic procedures for acylpyrazolones are reported …
acylpyrazolonate ligands. Novel synthetic procedures for acylpyrazolones are reported …
Ruthenium complexes: an emerging ground to the development of metallopharmaceuticals for cancer therapy
GLOBOCAN 2012 estimates 14.1 million new cancer cases and 8.2 million cancer-related
deaths worldwide. Cancer is rapidly becoming a major public health concern in India as …
deaths worldwide. Cancer is rapidly becoming a major public health concern in India as …