The proteins of mRNA modification: writers, readers, and erasers

MN Flamand, M Tegowski… - Annual review of …, 2023 - annualreviews.org
Over the past decade, mRNA modifications have emerged as important regulators of gene
expression control in cells. Fueled in large part by the development of tools for detecting …

N6-methyladenosine-mediated gene regulation and therapeutic implications

Y Liu, D Yang, T Liu, J Chen, J Yu, P Yi - Trends in molecular medicine, 2023 - cell.com
Abstract N6-methyladenosine (m 6 A) RNA methylation is the most abundant form of mRNA
modification in eukaryotes and is at the front line of biological and biomedical research. This …

RNA binding motif protein 45-mediated phosphorylation enhances protein stability of ASCT2 to promote hepatocellular carcinoma progression

D Du, M Qin, L Shi, C Liu, J Jiang, Z Liao, H Wang… - Oncogene, 2023 - nature.com
Targeting metabolic remodeling represents a potentially promising strategy for
hepatocellular carcinoma (HCC) therapy. In-depth understanding on the regulation of the …

Single-cell m6A profiling in the mouse brain uncovers cell type-specific RNA methylomes and age-dependent differential methylation

M Tegowski, AK Prater, CL Holley, KD Meyer - Nature Neuroscience, 2024 - nature.com
Abstract N 6-methyladenosine (m6A) is an abundant mRNA modification in the brain that
has important roles in neurodevelopment and brain function. However, because of technical …

RBM45 reprograms lipid metabolism promoting hepatocellular carcinoma via Rictor and ACSL1/ACSL4

C Wang, Z Chen, Y Yi, Y Ding, F Xu, H Kang, K Lin… - Oncogene, 2024 - nature.com
Reprogramming of lipid metabolism during hepatocarcinogenesis is not well elucidated.
Here, we aimed to explore pivotal RNA-binding motif proteins (RBMs) in lipid metabolism …

Emerging roles for DNA 6mA and RNA m6A methylation in mammalian genome

L Xie, X Zhang, J Xie, Y Xu, XJ Li, L Lin - International Journal of …, 2023 - mdpi.com
Epigenetic methylation has been shown to play an important role in transcriptional
regulation and disease pathogenesis. Recent advancements in detection techniques have …

Climate adaptation and drift shape the genomes of two eel-goby sister species endemic to contrasting latitude

Z Lü, T Liu, Y Liu, Y Wang, J Liu, B Liu, L Gong, L Liu - Animals, 2023 - mdpi.com
Simple Summary Climate is one of the most important drivers for adaptive evolution and
ecological speciation in teleost species. Using whole-genome re-sequencing technology …

Modifying the antiviral innate immune response by selective writing, erasing, and reading of m6A on viral and cellular RNA

CJ Aufgebauer, KM Bland, SM Horner - Cell Chem Biol, 2024 - cell.com
Viral infection and the antiviral innate immune response are regulated by the RNA
modification m6A. m6A directs nearly all aspects of RNA metabolism by recruiting RNA …

Structural basis for RNA recognition by the C-terminal RRM domain of human RBM45

X Chen, Q Wei, Z Yang, X Chen, S Guo, M Jiang… - Journal of Biological …, 2024 - jbc.org
RBM45 is an RNA-binding protein with roles in neural development by regulating RNA
splicing. Its dysfunction and aggregation are associated with neurodegenerative diseases …

Captive ERVWE1 triggers impairment of 5-HT neuronal plasticity in the first-episode schizophrenia by post-transcriptional activation of HTR1B in ALKBH5-m6A …

X Wu, L Liu, X Xue, X Li, K Zhao, J Zhang, W Li, W Yao… - Cell & Bioscience, 2023 - Springer
Background Abnormalities in the 5-HT system and synaptic plasticity are hallmark features
of schizophrenia. Previous studies suggest that the human endogenous retrovirus W family …