A simple, primary amine bearing a C10H15 alkyl residue was found to display potent anti-
Influenza A properties in 1964. 1 Soon thereafter, antiviral activity of this amine was found …

Owing to the unique DNA damaging cytotoxicity, platinum (Pt)-based chemotherapy has
long been the first-line choice for clinical oncology. Unfortunately, Pt drugs are restricted by …

Cisplatin is a chemotherapeutic drug that has been used in the treatment of various types of
human cancers such as ovarian, lung, head and neck, testicular and bladder. Cisplatin has …

Abstract Context: Progesterone (P4) influences ovarian cancer cells by an unknown
mechanism. Objective: The objective was to determine whether P4 acts through …

The ideal drug discovery process of new platinum based drugs should take into account
three basic fundaments: on one side the mechanisms of action and the corresponding target …

The naturally occurring coumestan wedelolactone has been previously shown to reduce
growth of various cancer cells. So far, the growth-suppressing effect of wedelolactone has …

Drug resistance induced by increasing intracellular levels of detoxifying agents for
conventional platinum (II) drugs such as metallothioneins (MTs) and glutathione (GSH) are …

In this study, we examined the mechanism of action of the novel epidermal growth factor
receptor (EGFR) tyrosine kinase inhibitor 5-benzylidene-hydantoin UPR1024, whose …

Ovarian cancer is one of the most lethal gynecological cancers; owning to its late detection
and chemoresistance, understanding the pathogenesis of this malignant tumor is much …

Background The initial pharmacokinetic study of a new anticancer agent (OC-6-43)-bis
(acetato)(1-adamantylamine) amminedichloroplatinum (IV)(LA-12) was complemented by …