Rebuilding the lid region from conformational and dynamic features to engineering applications of lipase in foods: Current status and future prospects

G Chen, IM Khan, W He, Y Li, P Jin… - … Reviews in Food …, 2022 - Wiley Online Library
The applications of lipases in esterification, amidation, and transesterification have
broadened their potential in the production of fine compounds with high cumulative values …

Enzyme kinetics, molecular docking, and in silico characterization of canary seed (Phalaris canariensis L.) peptides with ACE and pancreatic lipase inhibitory activity

U Urbizo-Reyes, AM Liceaga, L Reddivari… - Journal of Functional …, 2022 - Elsevier
The bioactivity of canary seed peptides (CSP) towards metabolism-regulating enzymes was
evaluated. Peptides with angiotensin-converting enzyme (ACE), dipeptidyl peptidase IV …

Inhibition of pancreatic lipase by the constituents in St. John's Wort: In vitro and in silico investigations

XD Hou, XQ Guan, YF Cao, ZM Weng, Q Hu… - International journal of …, 2020 - Elsevier
Herbal medicines are frequently used for the prevention and treatment of obesity and
obesity-related disorders. Our preliminary screening showed that St. John's Wort (SJW) …

Molecular physiology of insect midgut

WR Terra, IG Barroso, RO Dias, C Ferreira - Advances in insect physiology, 2019 - Elsevier
New approaches have led to advances in the molecular knowledge of digestion and nutrient
absorption in insects. Cell fractionation with proteomics revealed the molecular composition …

Lipase A from Bacillus subtilis: Substrate Binding, Conformational Dynamics, and Signatures of a Lid

S Behera, S Balasubramanian - Journal of Chemical Information …, 2023 - ACS Publications
Protein–ligand binding studies are crucial for understanding the molecular basis of
biological processes and for further advancing industrial biocatalysis and drug discovery …

Effective degradation of the mycotoxin patulin in pear juice by porcine pancreatic lipase

Y Xiao, B Liu, Z Wang, C Han, X Meng… - Food and Chemical …, 2019 - Elsevier
Porcine pancreatic lipase (PPL) was used to degrade the mycotoxin patulin (PAT) in pear
juice. The dosage of PPL, the initial concentration of PAT, reaction temperature and time …

Fluorometric probe for the lipase level: Design, mechanism and biological imaging application

P Guan, Y Liu, B Yang, Y Wu, J Chai, G Wen, B Liu - Talanta, 2021 - Elsevier
To realize accurate regulation for fluorescent substrate of lipase, two series compounds (I, II)
with similar structure were designed and synthesized. The flexible diphenylmethane was …

Voltammetric lipase activity assay based on dilinolein and a modified carbon paste electrode

A Rogala, J Rechberger, V Vasold, A Samphao… - Analytical and …, 2022 - Springer
In this work, a novel electrochemical assay for characterizing both lipases and lipase
inhibitors as well as for the determination of lipase activity is described. It is based on a …

Binding orientation and interaction of bile salt in its ternary complex with pancreatic lipase-colipase system

N Haque, NP Prabhu - Biochemical and biophysical research …, 2018 - Elsevier
The interfacial activity of pancreatic lipases (PL) depends on the presence of colipase and
bile salt. The activity of PL is inhibited by micellar concentrations of bile salt which can be …

Spontaneous lid closure and substrate-induced lid opening dynamics of human pancreatic lipase-related protein 2: A computational study

AK Sharath, N Haque, NP Prabhu - Journal of Molecular Structure, 2020 - Elsevier
Pancreatic lipases are essential dietary enzymes with a well-conserved catalytic triad
covered by a lid. Unlike classical lipases, pancreatic lipase-related proteins 2 (PLRP2) are …