The potential of the mevalonate pathway for enhanced isoprenoid production

P Liao, A Hemmerlin, TJ Bach, ML Chye - Biotechnology advances, 2016 - Elsevier
The cytosol-localised mevalonic acid (MVA) pathway delivers the basic isoprene unit
isopentenyl diphosphate (IPP). In higher plants, this central metabolic intermediate is also …

Glandular trichomes: what comes after expressed sequence tags?

A Tissier - The Plant Journal, 2012 - Wiley Online Library
Glandular trichomes cover the surface of many plant species. They exhibit tremendous
diversity, be it in their shape or the compounds they secrete. This diversity is expressed …

Metabolic engineering of microorganisms for the synthesis of plant natural products

J Marienhagen, M Bott - Journal of biotechnology, 2013 - Elsevier
Of more than 200,000 plant natural products known to date, many demonstrate important
pharmacological activities or are of biotechnological significance. However, isolation from …

Metabolic engineering of plant monoterpenes, sesquiterpenes and diterpenes—current status and future opportunities

BM Lange, A Ahkami - Plant biotechnology journal, 2013 - Wiley Online Library
Terpenoids (aka isoprenoids) represent the most diverse class of natural products found in
plants, with tens of thousands of reported structures. Plant‐derived terpenoids have a …

A review of biotechnological artemisinin production in plants

NKBK Ikram, HT Simonsen - Frontiers in Plant Science, 2017 - frontiersin.org
Malaria is still an eminent threat to major parts of the world population mainly in sub-
Saharan Africa. Researchers around the world continuously seek novel solutions to either …

Functional analysis of 3-hydroxy-3-methylglutaryl coenzyme a reductase encoding genes in triterpene saponin-producing ginseng

YJ Kim, OR Lee, JY Oh, MG Jang, DC Yang - Plant physiology, 2014 - academic.oup.com
Ginsenosides are glycosylated triterpenes that are considered to be important
pharmaceutically active components of the ginseng (Panax ginseng 'Meyer') plant, which is …

Artemisinins in combating viral infections like SARS-CoV-2, inflammation and cancers and options to meet increased global demand

K Farmanpour-Kalalagh… - Frontiers in Plant …, 2022 - frontiersin.org
Artemisinin is a natural bioactive sesquiterpene lactone containing an unusual
endoperoxide 1, 2, 4-trioxane ring. It is derived from the herbal medicinal plant Artemisia …

Variation in terpenoids in leaves of Artemisia annua grown under different LED spectra resulting in diverse antimalarial activities against Plasmodium falciparum

D Sankhuan, G Niramolyanun, N Kangwanrangsan… - BMC Plant …, 2022 - Springer
Background Productivities of bioactive compounds in high-value herbs and medicinal plants
are often compromised by uncontrollable environmental parameters. Recent advances in …

From plant to yeast—Advances in biosynthesis of artemisinin

L Zhao, Y Zhu, H Jia, Y Han, X Zheng, M Wang… - Molecules, 2022 - mdpi.com
Malaria is a life-threatening disease. Artemisinin-based combination therapy (ACT) is the
preferred choice for malaria treatment recommended by the World Health Organization. At …

Plants as sources of natural and recombinant antimalaria agents

P Habibi, Y Shi, M Fatima Grossi-de-Sa, I Khan - Molecular biotechnology, 2022 - Springer
Malaria is one of the severe infectious diseases that has victimized about half a civilization
billion people each year worldwide. The application of long-lasting insecticides is the main …