A fundamental goal in cancer research is to understand the mechanisms of cell
transformation. This is key to developing more efficient cancer detection methods and …

Pancreatic cancer is a genetic disease, and the recurrent genetic alterations characteristic of
pancreatic cancer indicate the cellular processes that are targeted for malignant …

DNA damage repair (DDR) pathways modulate cancer risk, progression, and therapeutic
response. We systematically analyzed somatic alterations to provide a comprehensive view …

Lung cancer is the world's leading cause of cancer death and shows strong ancestry
disparities. By sequencing and assembling a large genomic and transcriptomic dataset of …

The increase in available high-throughput molecular data creates computational challenges
for the identification of cancer genes. Genetic as well as non-genetic causes contribute to …

Identifying molecular cancer drivers is critical for precision oncology. Multiple advanced
algorithms to identify drivers now exist, but systematic attempts to combine and optimize …

Hotspot mutations in splicing factor genes have been recently reported at high frequency in
hematological malignancies, suggesting the importance of RNA splicing in cancer. We …

Summary The Cancer Genome Atlas (TCGA) has catalyzed systematic characterization of
diverse genomic alterations underlying human cancers. At this historic junction marking the …

Cancer genomes contain large numbers of somatic mutations but few of these mutations
drive tumor development. Current approaches either identify driver genes on the basis of …

Standard CRISPR-mediated gene disruption strategies rely on Cas9-induced DNA double-
strand breaks (DSBs). Here, we show that CRISPR-dependent base editing efficiently …