Genomic instability is the hallmark of various cancers with the increasing accumulation of
DNA damage. The application of radiotherapy and chemotherapy in cancer treatment is …

There is highly credible evidence that melatonin mitigates cancer at the initiation,
progression and metastasis phases. In many cases, the molecular mechanisms …

This introductory article should be viewed as a prologue to the Free Radical Biology &
Medicine Special Issue devoted to the important topic of Oxidatively Damaged DNA and its …

Covalent DNA–protein crosslinks (DPCs) are pervasive DNA lesions that interfere with
essential chromatin processes such as transcription or replication. This review strives to …

Clustered DNA damage is related to the biological effects of ionizing radiation. However, its
precise yield and complexity (ie, number of lesions per damaged site) in vivo remain …

In present times, the levels of ionizing radiation (IR) on the surface of Earth are relatively low,
posing no high challenges for the survival of contemporary life forms. IR derives from natural …

Thoracic radiotherapy patients have higher risks of developing radiation-induced heart
disease (RIHD). Ionizing radiation generates excessive reactive oxygens species (ROS) …

Repair of covalent DNA-protein crosslinks (DPCs) by DNA-dependent proteases has
emerged as an essential genome maintenance mechanism required for cellular viability and …

Proteins that are covalently bound to DNA constitute a specific type of DNA lesion known as
DNA–protein crosslinks (DPCs). DPCs represent physical obstacles to the progression of …

Accurate duplication of chromosomal DNA is essential for the transmission of genetic
information. The DNA replication fork encounters template lesions, physical barriers …