A brief guideline for studies of phase-separated biomolecular condensates
Y Gao, X Li, P Li, Y Lin - Nature Chemical Biology, 2022 - nature.com
Cells are exquisitely compartmentalized to achieve precise spatiotemporal regulation of
myriad processes and pathways. Phase separation offers one way to achieve territorial …
myriad processes and pathways. Phase separation offers one way to achieve territorial …
[HTML][HTML] Molecular mechanisms of stress granule assembly and disassembly
S Hofmann, N Kedersha, P Anderson… - Biochimica et Biophysica …, 2021 - Elsevier
Stress granules (SGs) are membrane-less ribonucleoprotein (RNP)-based cellular
compartments that form in the cytoplasm of a cell upon exposure to various environmental …
compartments that form in the cytoplasm of a cell upon exposure to various environmental …
Competing protein-RNA interaction networks control multiphase intracellular organization
Liquid-liquid phase separation (LLPS) mediates formation of membraneless condensates
such as those associated with RNA processing, but the rules that dictate their assembly …
such as those associated with RNA processing, but the rules that dictate their assembly …
[HTML][HTML] Single-molecule imaging reveals translation of mRNAs localized to stress granules
Cellular stress leads to reprogramming of mRNA translation and formation of stress granules
(SGs), membraneless organelles consisting of mRNA and RNA-binding proteins. Although …
(SGs), membraneless organelles consisting of mRNA and RNA-binding proteins. Although …
A new phase of networking: the molecular composition and regulatory dynamics of mammalian stress granules
SR Millar, JQ Huang, KJ Schreiber, YC Tsai… - Chemical …, 2023 - ACS Publications
Stress granules (SGs) are cytosolic biomolecular condensates that form in response to
cellular stress. Weak, multivalent interactions between their protein and RNA constituents …
cellular stress. Weak, multivalent interactions between their protein and RNA constituents …
Higher-order organization of biomolecular condensates
A guiding principle of biology is that biochemical reactions must be organized in space and
time. One way this spatio-temporal organization is achieved is through liquid–liquid phase …
time. One way this spatio-temporal organization is achieved is through liquid–liquid phase …
Spatiotemporal proteomic analysis of stress granule disassembly using APEX reveals regulation by SUMOylation and links to ALS pathogenesis
H Marmor-Kollet, A Siany, N Kedersha, N Knafo… - Molecular cell, 2020 - cell.com
Stress granules (SGs) are cytoplasmic assemblies of proteins and non-translating mRNAs.
Whereas much has been learned about SG formation, a major gap remains in …
Whereas much has been learned about SG formation, a major gap remains in …
Stress-related biomolecular condensates in plants
J Solis-Miranda, M Chodasiewicz, A Skirycz… - The Plant …, 2023 - academic.oup.com
Biomolecular condensates are membraneless organelle-like structures that can concentrate
molecules and often form through liquid-liquid phase separation. Biomolecular condensate …
molecules and often form through liquid-liquid phase separation. Biomolecular condensate …
Mechanisms and regulation of RNA condensation in RNP granule formation
Ribonucleoprotein (RNP) granules are RNA–protein assemblies that are involved in
multiple aspects of RNA metabolism and are linked to memory, development, and disease …
multiple aspects of RNA metabolism and are linked to memory, development, and disease …
Inhibition of anti-viral stress granule formation by coronavirus endoribonuclease nsp15 ensures efficient virus replication
Cytoplasmic stress granules (SGs) are generally triggered by stress-induced translation
arrest for storing mRNAs. Recently, it has been shown that SGs exert anti-viral functions due …
arrest for storing mRNAs. Recently, it has been shown that SGs exert anti-viral functions due …